ID A0A4S8IYI3_MUSBA Unreviewed; 1324 AA.
AC A0A4S8IYI3;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=tRNA(adenine(34)) deaminase {ECO:0000256|ARBA:ARBA00012740};
DE EC=3.5.4.33 {ECO:0000256|ARBA:ARBA00012740};
GN ORFNames=C4D60_Mb10t10160 {ECO:0000313|EMBL:THU53032.1};
OS Musa balbisiana (Banana).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zingiberales; Musaceae; Musa.
OX NCBI_TaxID=52838 {ECO:0000313|EMBL:THU53032.1, ECO:0000313|Proteomes:UP000317650};
RN [1] {ECO:0000313|EMBL:THU53032.1, ECO:0000313|Proteomes:UP000317650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH-PKW {ECO:0000313|Proteomes:UP000317650};
RC TISSUE=Leaves {ECO:0000313|EMBL:THU53032.1};
RA Yao X.;
RT "Genome sequencing of Musa balbisiana reveals subgenome evolution and
RT function divergence in polyploid bananas.";
RL Nat. Plants 0:0-0(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC Evidence={ECO:0000256|ARBA:ARBA00001103};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:THU53032.1}.
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DR EMBL; PYDT01000008; THU53032.1; -; Genomic_DNA.
DR STRING; 52838.A0A4S8IYI3; -.
DR Proteomes; UP000317650; Chromosome 10.
DR GO; GO:0052717; F:tRNA-specific adenosine-34 deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:InterPro.
DR CDD; cd01285; nucleoside_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR HAMAP; MF_00972; tRNA_aden_deaminase; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR028883; tRNA_aden_deaminase.
DR PANTHER; PTHR11079:SF179; CYTOSINE DEAMINASE; 1.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR Pfam; PF14437; MafB19-deam; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000317650};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 1122..1244
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
FT REGION 827..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1324 AA; 148719 MW; 2308935A831F54FC CRC64;
MYGGHAAATF AVRAKSSVCH SRRLSLLDDG GGDEFALHGL SINRRFMLYG YYSRQSSLIY
WSHLRTFLAG HGGHHYLRLS LRDVQPCAPR VPARRGGFRA CCCCRSPQPR FQMAGECCRE
SFDDGMWEDD ADYVEFGDMT RHSKREVKIR PVDAEKVRSL RARKDASSSV CHSCGHENKM
SGGLSSGGKK CYTGKKVNAA VREVRKGWKM DDDVDYDSRE ESDYRDRNYN VRDLTSARVS
NRKTEGRAAK LIASAYQEKE DHHFKVEDKV KKRDSREGSR KFANIVKVDD NVDVANSFID
MADLKKVDRD KRVVEQDKQE VEQRGASCSF LAHGRRDEYY LGRQNIIGRE SREGSQKSVI
ASDVHEDDMM MTSRPKRHVD ERKVDMAESS LKQHGQVDKR VVRRAESRTE VGDEYVNNEN
QVAVLRESIE GSQRSRRIPE VHEDNAERIA SAESMLDTRK VDKEHSSTSI MKKHTAVGQQ
AVRSYESREQ LQNFRQIEEV HNSNIKKVSN KEKRHEEVLV KNRDDKSISV HMARDNRGHI
GQQIIDKMEL GKQYENQVDV SRPHVRGTES ASSSQSLLQS RINDRVDYST SIMNPIHQVE
KHQTQSENQY TYQYSPKRES GKAMCTSELP RKDSGKVSTA QVMYNADIQN ELNNCQYSSR
RECETDARMS EYAVTDIQRN FNLQNISNMR IGNGKERSSL LMVQDDKKKL GTLTGESSQP
INQEITSLGA FDGDSSFLDT HMQQPDDPAC GDENYLVKSD TLDSASRLES SSAMYVGEFV
DKLRHESSTF ISSGTQTEKA HGKGIQATTS MQSDRLVATI TEKDEKYIQE GSGRSSRSGI
RGPSDEMWDV RSLISQKDGR KEEQGEHGLS AGVIDSTTTT PTVENTIAGR SPKSLWAHIS
DIMRMGWVHR AESHTSNQKS GKRSSSEGSE AWFSGQDASD DENDPNARSS EIKELLPVAV
PVDRGHETHS SITQGCFQAP DVVVMQLGGG ASTSMTTAGG YASKGASANS RPEQTTLAEN
EKGTKSIISR AVTVDKPSLM TGDASSVAID EGITYTGNLT VPVSGYTNFE EDLLREEPPE
ADKTEGKDGE LKRRKLQRNK QVLKETFEEW EEAYRFESEQ RKIDEYFMRE ALVEAQKAAD
IWEVPVGAVL VQNGKIIARG FNLVEERRDS TAHAEMICIR EASNLLRTWR LAETTLYVTL
EPCPMCAGAI LQARVDTVVW GAPNKLLGAD GSWIRLFPGD NGGSSSLDPS SQMAGPVHPF
HPNIRIRRGV LATECSDVLQ QFFQLRRKKK KKPESPPQSC LPVPNHPIKL FTRMHNIFSV
MFCL
//
