ID   A0A4U0U5W6_9PEZI        Unreviewed;       625 AA.
AC   A0A4U0U5W6;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN   ORFNames=B0A50_02554 {ECO:0000313|EMBL:TKA30327.1};
OS   Salinomyces thailandica.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Salinomyces.
OX   NCBI_TaxID=706561 {ECO:0000313|EMBL:TKA30327.1, ECO:0000313|Proteomes:UP000308549};
RN   [1] {ECO:0000313|EMBL:TKA30327.1, ECO:0000313|Proteomes:UP000308549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCFEE 6315 {ECO:0000313|EMBL:TKA30327.1,
RC   ECO:0000313|Proteomes:UP000308549};
RA   Coleine C., Masonjones S., Stajich J.E.;
RT   "Genomes of endolithic fungi from Antarctica.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC         ChEBI:CHEBI:57924; EC=1.14.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000426};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC         ChEBI:CHEBI:58315; EC=1.14.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001038};
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TKA30327.1}.
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DR   EMBL; NAJL01000011; TKA30327.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4U0U5W6; -.
DR   Proteomes; UP000308549; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.60.310.20; -; 1.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 2.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR041640; Tyrosinase_C.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF32; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF18132; Tyosinase_C; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000308549};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..625
FT                   /note="tyrosinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5020260516"
FT   DOMAIN          130..147
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          306..317
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   625 AA;  69106 MW;  11087219F9050E57 CRC64;
     MAAPSFMRRV LLAIALLHAV LLTSCSPLLS HQVEELAAPE APTLQRRQSS LTLVTGITAF
     GVQPRLEIRE LQQNADQWNI YLLGLVRWQA VNETEKLSYY QIAGIHGRPY AAWDGVPAEE
     NITRPGYCMH VSNVFLPWHR PYLALYEQTL YQHMVDAVNA FPAGATRQRY AAAALSWRMP
     YWDWAATPAD GESVYPSAVT TSTVTVTMPN GTNTIPNPLY TYHFHPVKQA DFYFNPFSSW
     NVTIRAPTNW TSNAISQNGK VGSDLDNSRV SFQDRVYNLL TFYSNFTQFG NEAWIDPGVS
     NADTYDPLFW LHHAMVDRIF ALWQALYNDS YVEPMAAVEQ SFTVAINDHV DENTPLKPFH
     ANANGDMWTA ATVRSPQTLG YTYSDLGNGS ISAVKAAVNR LYGRSAGSGG ISKRSGDARV
     NVQRELPEAA VENASVTAPE DIIDGRNRQY LANILSQKFA LNGSYGIYLF MGDFDDDPAS
     WPQSPNLVGT HAVFAALSTA DAASNPQART KRDGSLIHVT GAMPLTSMLL AKVDAGDISC
     MNPETVIPYL TDNLHWRVGM FDGSQIEPQD VADLTITVIS AEVEPASRDD QFPQWSNFEV
     LTSITQGKPG GALFLGHERR PIAHK
//