ID A0A4U1EP29_MONMO Unreviewed; 500 AA.
AC A0A4U1EP29;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Protein S100-A4 {ECO:0000256|ARBA:ARBA00023809};
DE AltName: Full=Calcyclin {ECO:0000256|ARBA:ARBA00032106};
DE AltName: Full=Metastasin {ECO:0000256|ARBA:ARBA00031687};
DE AltName: Full=Protein S100-A6 {ECO:0000256|ARBA:ARBA00014225};
DE AltName: Full=S100 calcium-binding protein A4 {ECO:0000256|ARBA:ARBA00032790};
DE AltName: Full=S100 calcium-binding protein A6 {ECO:0000256|ARBA:ARBA00032794};
DE Flags: Fragment;
GN ORFNames=EI555_010730 {ECO:0000313|EMBL:TKC38152.1};
OS Monodon monoceros (Narwhal) (Ceratodon monodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Monodon.
OX NCBI_TaxID=40151 {ECO:0000313|EMBL:TKC38152.1, ECO:0000313|Proteomes:UP000308365};
RN [1] {ECO:0000313|Proteomes:UP000308365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31054839; DOI=10.1016/j.isci.2019.03.023;
RA Westbury M.V., Petersen B., Garde E., Heide-Jorgensen M.P., Lorenzen E.D.;
RT "Narwhal Genome Reveals Long-Term Low Genetic Diversity despite Current
RT Large Abundance Size.";
RL IScience 15:592-599(2019).
CC -!- FUNCTION: May function as calcium sensor and modulator, contributing to
CC cellular calcium signaling. May function by interacting with other
CC proteins, such as TPR-containing proteins, and indirectly play a role
CC in many physiological processes such as the reorganization of the actin
CC cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium
CC binding is cooperative. {ECO:0000256|ARBA:ARBA00025385}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the S-100 family.
CC {ECO:0000256|ARBA:ARBA00007323}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TKC38152.1}.
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DR EMBL; RWIC01001036; TKC38152.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U1EP29; -.
DR Proteomes; UP000308365; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 2.
DR CDD; cd05029; S-100A6; 1.
DR Gene3D; 1.10.238.10; EF-hand; 5.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR034118; S-100A6.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR11639:SF51; PROTEIN S100-A4; 1.
DR PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1.
DR Pfam; PF01023; S_100; 5.
DR SMART; SM00054; EFh; 4.
DR SMART; SM01394; S_100; 5.
DR SUPFAM; SSF47473; EF-hand; 4.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00303; S100_CABP; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000308365}.
FT DOMAIN 265..300
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 458..493
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 370..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:TKC38152.1"
SQ SEQUENCE 500 AA; 55498 MW; 759663D998471985 CRC64;
ALAVMVTTFH KYSGQEGDNF KLSKGEMKKL LHKELPSFVG KKVDEEGLKR MMGDLDKNRD
QEVDFQGYAL SLALDTVMCN DFFQGFPAHL GDEGDLAGQS PDALGVSILN PRGITMAPLE
QAVAAIVCTF QEYSGPCWRQ VKLCQAELKE LLEKELPTWT PTELRECDHN KFMSVLDTSK
DREVDFVEYT CLLACLCACC HEYFKNCALG PHCSHMACPL EKALDVMVST FHKYSGKEGD
KFKLNKSELK ELLTRELPSF LGKKTDEAAF QKLMSNLDSN KDNEVDFQEY CVFLACIAMM
CNESCLGGTG IFKEEPPELH TMLETSLEKA LTTVVTTFHK YSGREGSKLT LSRKELKELI
EKDLCLGEGG ARAGSGRPAS RKRRYKAGGL ATRPSPSAAP SRFAAAAPSA MACPLDQAIG
LLVTIFHKYS SQEGDKNTLS KSELKELIQK ELTIGAKLQD AEIAKLMDDL DRNKDQVVNF
QEYVTFLGAL AMIYNDILRG
//
