ID   A0A4U1FJ95_MONMO        Unreviewed;       710 AA.
AC   A0A4U1FJ95;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Nardilysin convertase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EI555_010457 {ECO:0000313|EMBL:TKC49975.1};
OS   Monodon monoceros (Narwhal) (Ceratodon monodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Monodon.
OX   NCBI_TaxID=40151 {ECO:0000313|EMBL:TKC49975.1, ECO:0000313|Proteomes:UP000308365};
RN   [1] {ECO:0000313|Proteomes:UP000308365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=31054839; DOI=10.1016/j.isci.2019.03.023;
RA   Westbury M.V., Petersen B., Garde E., Heide-Jorgensen M.P., Lorenzen E.D.;
RT   "Narwhal Genome Reveals Long-Term Low Genetic Diversity despite Current
RT   Large Abundance Size.";
RL   IScience 15:592-599(2019).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TKC49975.1}.
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DR   EMBL; RWIC01000098; TKC49975.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4U1FJ95; -.
DR   Proteomes; UP000308365; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000308365}.
FT   DOMAIN          32..97
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          168..279
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          414..579
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   710 AA;  81933 MW;  5F8B24011F2CA0DB CRC64;
     MIRDAIDREV EAVDSGNAET LKHEPKRNNI DTHARLREFW MHYYSAHYMT LVVQSKETLD
     TLEKWVTEIF SQIPNKKIHA LTITWALPPQ QQHYRCWALA LFGGNGETGF EQNSTYSVFS
     ISITLTDEGY EHFYEVAHTV FQYLKMLQKL GPEKRIFEEI QKIEDNEFHY QEQTDPVEYV
     ENMCENMQLY PLQDFLTGDQ LLFEYKPEVI AEALNQLVPQ KANLVLLSGA NEGKCDLKEK
     WFGTQYSMED IENSWAELWE SNFELNPDLH LPAENKYIAY IRFHLISPLI QKSAANVVLF
     DIFVNILTHN LAEPAYEADV AQLEYKLVAG EHGLIIRVKG FNHKLPLLFQ LIIDYLAEFS
     STPAVFTMIT EQLKKTYFNI LIKPETLAKD VRLLILEYAR WSMIDKYRAL MDGLSLESLL
     SFVRELKSQL FVEGLVQGNV TSTESMDFLK YVVDKLNFMP LEQEMPVQFQ VVELPSGHHL
     CKVRALNKGD ANSEVTVYYQ MHMEEPCFDF LRTKQTLGYH VYPTCRNTSG ILGFSVTVGT
     QATKYNSEVV DKKIEEFLSS FEEKIENLTE DAFNTQVTAL IKLKECEDTH LGEEVDRNWN
     EVVTQQYLFD RLAHEIEALK SFSKSDLVNW FKAHRGPGSK MLSVHVVGFG KYEPEEDGTP
     SSEDSNSSCE VMQLTYLPTS PLLADCTIPV IDIRAFTSRL NLLPYHKIVK
//