ID A0A4U5M618_STECR Unreviewed; 929 AA.
AC A0A4U5M618;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=L596_024820 {ECO:0000313|EMBL:TKR64252.1};
OS Steinernema carpocapsae (Entomopathogenic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC Steinernema.
OX NCBI_TaxID=34508 {ECO:0000313|EMBL:TKR64252.1, ECO:0000313|Proteomes:UP000298663};
RN [1] {ECO:0000313|EMBL:TKR64252.1, ECO:0000313|Proteomes:UP000298663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALL {ECO:0000313|EMBL:TKR64252.1,
RC ECO:0000313|Proteomes:UP000298663};
RX PubMed=26392177; DOI=10.1186/s13059-015-0746-6;
RA Dillman A.R., Macchietto M., Porter C.F., Rogers A., Williams B.,
RA Antoshechkin I., Lee M.M., Goodwin Z., Lu X., Lewis E.E.,
RA Goodrich-Blair H., Stock S.P., Adams B.J., Sternberg P.W., Mortazavi A.;
RT "Comparative genomics of Steinernema reveals deeply conserved gene
RT regulatory networks.";
RL Genome Biol. 16:200-200(2015).
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TKR64252.1}.
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DR EMBL; AZBU02000009; TKR64252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U5M618; -.
DR STRING; 34508.A0A4U5M618; -.
DR Proteomes; UP000298663; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR CDD; cd17006; ANTH_N_HIP1_like; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000298663}.
FT DOMAIN 10..139
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 674..915
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 338..433
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 462..531
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 874..910
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 929 AA; 104057 MW; 472A323B406020F3 CRC64;
MSRSSVNSMD REAFIKSQLV AVNKALNKVE APLKQKHVRT LILGTHREKS ANVFWNTVSR
FQLEKNPVLT WKFCHCLHKL IRDGHRKVIE DSNRYSTRLV TLGSFWQHLR TSGYGASNTA
YLKMLVSRLE FHKRNPSIPG NFNLNESQLN AVISADINDL YELAVELLDQ MDDALTLQAN
VHDTLECLRF SSLVPQGQCL LAPLILVILD TSKLYDYLVK LLFKLHSSCP ADMLSGHRER
FNVIFRKTKK FYEEANSLQY FKYLVSIPTL PAQPPNFLMA TDFDSYRSPQ AYLHGDGASE
CDTPPDAQSL AEETLIDISA PEPVAVQPLQ AMPCRDHRDD LIDQMRRDLE EVQAARERLL
NEARQRIEQY ENRLLQMQHE IEKQRQSADD AREEANRLKS AQMASTMDLG AKNQEYEKKI
LDKEEKFQKM KGVYGNLREE HIRALTEIGD LRKKLAEQEN ASMSNDDMLR QLNRRIEETE
RERSLVEERA QQSSSSLDEL NSQLARCQIE IEDLHKAAEE AKEKHQAELV QKGRSSLEGA
CEAALQMMEQ SLEELQNATT ISYPPQLAIS ALKNTVEHVN KLDASVPSEQ LINNVAYVGH
CLAEDVVHTA AAAYTASIQH FEPVNDQCRA VADSAISAFK SIKADPESAQ NSISELKSKL
TELDRLCDAL PTSSGDIDVE AVGSQMEDEM KRMDAAIQAA VDAIEAIQRK ARENNSGIRL
EVNEKILDAC NALMAAIMIL VARSRDVQNE IVAAGRGTAS PSEFYKRNHQ WTEGLLSAAQ
AVGVAAKVLV NSADGVVTGE GKFEHLIVAA QEIAASIAQL YVSSRVKADK DSQKLSELAS
ATKSVNSCTA NVVATVKSGQ QTLSDEKMLD FSHLSLHEAK KEEMESQVKM LELEQELTQE
RARLAQLRKQ HYHMASLVAE QNSNGNGNS
//
