ID A0A4U5PH34_STECR Unreviewed; 72 AA.
AC A0A4U5PH34;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 22-FEB-2023, entry version 11.
DE RecName: Full=Tubulin-specific chaperone A {ECO:0000256|ARBA:ARBA00015002, ECO:0000256|RuleBase:RU364030};
GN ORFNames=L596_009754 {ECO:0000313|EMBL:TKR95611.1};
OS Steinernema carpocapsae (Entomopathogenic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC Steinernema.
OX NCBI_TaxID=34508 {ECO:0000313|EMBL:TKR95611.1, ECO:0000313|Proteomes:UP000298663};
RN [1] {ECO:0000313|EMBL:TKR95611.1, ECO:0000313|Proteomes:UP000298663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALL {ECO:0000313|EMBL:TKR95611.1,
RC ECO:0000313|Proteomes:UP000298663};
RX PubMed=26392177; DOI=10.1186/s13059-015-0746-6;
RA Dillman A.R., Macchietto M., Porter C.F., Rogers A., Williams B.,
RA Antoshechkin I., Lee M.M., Goodwin Z., Lu X., Lewis E.E.,
RA Goodrich-Blair H., Stock S.P., Adams B.J., Sternberg P.W., Mortazavi A.;
RT "Comparative genomics of Steinernema reveals deeply conserved gene
RT regulatory networks.";
RL Genome Biol. 16:200-200(2015).
CC -!- FUNCTION: Tubulin-folding protein; involved in the early step of the
CC tubulin folding pathway. {ECO:0000256|ARBA:ARBA00003046}.
CC -!- SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D
CC function by capturing and stabilizing tubulin in a quasi-native
CC conformation. Cofactor E binds to the cofactor D-tubulin complex;
CC interaction with cofactor C then causes the release of tubulin
CC polypeptides that are committed to the native state.
CC {ECO:0000256|ARBA:ARBA00026055, ECO:0000256|RuleBase:RU364030}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|RuleBase:RU364030}.
CC -!- SIMILARITY: Belongs to the TBCA family. {ECO:0000256|ARBA:ARBA00006806,
CC ECO:0000256|RuleBase:RU364030}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TKR95611.1}.
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DR EMBL; AZBU02000002; TKR95611.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U5PH34; -.
DR Proteomes; UP000298663; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR004226; TBCA.
DR InterPro; IPR036126; TBCA_sf.
DR Pfam; PF02970; TBCA; 1.
DR SUPFAM; SSF46988; Tubulin chaperone cofactor A; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU364030};
KW Cytoplasm {ECO:0000256|RuleBase:RU364030};
KW Cytoskeleton {ECO:0000256|RuleBase:RU364030};
KW Microtubule {ECO:0000256|RuleBase:RU364030};
KW Reference proteome {ECO:0000313|Proteomes:UP000298663}.
SQ SEQUENCE 72 AA; 7976 MW; FEDCD386A221C39A CRC64;
MSAEATTEVE EYNAKKMAEV AQESQQMIGN SKRRMESTAN EFLKLLDDNQ AELKEAAELV
TEAKLQIEAA GI
//
