ID A0A4U5UFS0_COLLU Unreviewed; 994 AA.
AC A0A4U5UFS0;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|EMBL:TKS72958.1};
GN ORFNames=D9C73_007035 {ECO:0000313|EMBL:TKS72958.1};
OS Collichthys lucidus (Big head croaker) (Sciaena lucida).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Collichthys.
OX NCBI_TaxID=240159 {ECO:0000313|EMBL:TKS72958.1, ECO:0000313|Proteomes:UP000298787};
RN [1] {ECO:0000313|EMBL:TKS72958.1, ECO:0000313|Proteomes:UP000298787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JT15FE1705JMU {ECO:0000313|EMBL:TKS72958.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TKS72958.1};
RA Cai M., Xiao S.;
RT "Genome Assembly of Collichthys lucidus.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; CM014084; TKS72958.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U5UFS0; -.
DR STRING; 240159.A0A4U5UFS0; -.
DR Proteomes; UP000298787; Chromosome 7.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000298787};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..112
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 140..647
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 656..750
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 787..993
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 90..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 109296 MW; B1EA02A07B7C868B CRC64;
MELPVASDGV HLAAYRPRRP LSAANGKEAP GGYDESGFYQ CYGDGGSVAS RGSDALTGYE
TLDSPPHYDF YANTEVWGRR RHFRPSLYQL YSNPEDNSGP PLYEETTGGR MEEGGENSEE
DEEEQKEPPP EPLRFGWVQG VMIRCMLNIW GVILYLRLPW ITAQAGIGLT WVIILLSSCI
TGITGLSTSA IATNGKVKKG GTYFLISRSL GPELGGSIGL IFAFANAVAV AMHTVGFAET
VTDIMRENGA VMVDRTNDIR IIGIITVTCL LGISMAGMAW ESKAQILFFL VIVVSFASYF
VGTILPASPQ KQAKGFFSYK ADIFAVNFVP SWRGQDGSFF GMFSIFFPSA TGILAGANIS
GDLKNPAVAI PRGTLMAIFW TTFSYIIISA TIGACVVRDA SGLLNDTVSA SSSSEGCVGL
ACQYGWDFTE CINNNTCTYG ISNYYQSMSM VSAFSPLITA GIFGATLSSA LACLVSAPKV
FQCLCKDKLY PLIGFFGKGY GKNEEPLRSY LLTYVIAACF ILIAELNTIA PIISNFFLCS
YSLINFSCFH ASITNSPGWR PSFRFYSKWL SLLGAVCCVV IMFLLNWWAA LIAFGIVLVL
LGYTLYKKPA VNWGSSVQAS SYNMALNQCV GLNHVEDHVK NYRPQCLVLT GPPSSRPALV
DLVTCFTKSL SLMMCANVVT SSPSPSVVEE ASSDSHVTWL NRRKVKSFYR GVVAGELRSG
VNMLLQGAGL GRMKPNVLLM GFKKNWCSDT PEAAHINPGF DGGPEGISTI SAPPCIQTST
TSTVSIEAEP QPSTVFQKKQ GKKTIDVYWL SDDGGLTLLL PYLLTRRKRW ARCKVRVFVG
GEMDQKEKQR EEVLALIKRF RLGFHDVEVL PDIYQNPQPA NVHQFENMVS RFRLDPNPKQ
DSGPPRQQEE PWMITNQDLE RNKAKSLRQI RLNEVLQDYS REAALIVITM PVGRRGVCPS
TLYLAWLDFL SRDLRPPVLL VRGNQESVLT FYCQ
//
