ID A0A4U5UYX1_COLLU Unreviewed; 352 AA.
AC A0A4U5UYX1;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Integrin-linked kinase-associated serine/threonine phosphatase 2C {ECO:0000313|EMBL:TKS80577.1};
GN ORFNames=D9C73_014679 {ECO:0000313|EMBL:TKS80577.1};
OS Collichthys lucidus (Big head croaker) (Sciaena lucida).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Collichthys.
OX NCBI_TaxID=240159 {ECO:0000313|EMBL:TKS80577.1, ECO:0000313|Proteomes:UP000298787};
RN [1] {ECO:0000313|EMBL:TKS80577.1, ECO:0000313|Proteomes:UP000298787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JT15FE1705JMU {ECO:0000313|EMBL:TKS80577.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TKS80577.1};
RA Cai M., Xiao S.;
RT "Genome Assembly of Collichthys lucidus.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|RuleBase:RU003465}.
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DR EMBL; CM014090; TKS80577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U5UYX1; -.
DR STRING; 240159.A0A4U5UYX1; -.
DR Proteomes; UP000298787; Chromosome 13.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR47992; PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR47992:SF105; PROTEIN PHOSPHATASE 1B; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW Integrin {ECO:0000313|EMBL:TKS80577.1};
KW Kinase {ECO:0000313|EMBL:TKS80577.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU003465};
KW Reference proteome {ECO:0000313|Proteomes:UP000298787};
KW Transferase {ECO:0000313|EMBL:TKS80577.1}.
FT DOMAIN 66..347
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 39524 MW; AD4403F716444D8F CRC64;
MDLFDDLPEP TQTSAPVPGA RPLSTKEEEE EEEEEEERRF KRRRGDGAEE EQEEVKRVCK
EGLPVLRGYV AARRGERDEM QDAHVLLPDM NGYLSALPGR VSRVSYFAVF DGHGGARASR
FAAENLHHNL AKKFPSGETE NVDKLIKKCL VDTFRQTDEE FLKKASSQKP AWKDGSTATC
VLVVDDTVYV ANLGDSRVCW DCFSVTTRRA VTLALSKEHN PTIYEERMRI QRAGGTVRDG
RVLGVLEVSR SIGDGQYKRC GVISTPDLRR CQLTANDRRE HRHTLTADWL DEEITPPRDV
TFVPSVSPIM GNQLASEAVR RGSQLQYRVL TRAVRDGCDV LVTVMKLCAS TP
//