ID A0A4U8S5C5_9HELI Unreviewed; 1796 AA.
AC A0A4U8S5C5;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 13-SEP-2023, entry version 10.
DE SubName: Full=Alpha-2-macroglobulin family protein {ECO:0000313|EMBL:TLD81054.1};
GN ORFNames=LS68_006210 {ECO:0000313|EMBL:TLD81054.1};
OS Helicobacter sp. MIT 05-5293.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1548149 {ECO:0000313|EMBL:TLD81054.1, ECO:0000313|Proteomes:UP000029872};
RN [1] {ECO:0000313|EMBL:TLD81054.1, ECO:0000313|Proteomes:UP000029872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 05-5293 {ECO:0000313|EMBL:TLD81054.1,
RC ECO:0000313|Proteomes:UP000029872};
RX PubMed=25428971;
RA Sheh A., Shen Z., Fox J.G.;
RT "Draft genome sequences of eight enterohepatic helicobacter species
RT isolated from both laboratory and wild rodents.";
RL Genome Announc. 2:e01218-e01214(2014).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TLD81054.1}.
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DR EMBL; JROZ02000002; TLD81054.1; -; Genomic_DNA.
DR STRING; 1548149.LS68_04655; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000029872; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR032812; SbsA_Ig.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF13205; Big_5; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 923..1065
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1132..1221
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1796 AA; 203208 MW; 00A2B0C5F3BF8887 CRC64;
MKHCFKIQYW LISLIVLLFV ACSDKNEIVA DYSSKIATTD EIFITFEQPI ISEENRRFIH
QHSTKDNAIK LNGKAFEGSY SFATDSKLLI APHFPLEPNT DYTLEVNLAN LKDSHLKDKL
KLSLHTNPTH FDYTFTHIYD KSGFNTLEAQ IEFSQKINLE NLKDSLSLKC TESKKVDFEL
MPTSSTSIAV KSAPIAASEK EVECELTLDA KSIGLEKKEV LRYVFAGKPD LEITKIEAIP
DANPSIEVSF SQEIKNENLQ NFVQLKPDIK AKISKSYNKL IINAPFDRLQ SYTLTLVEGL
KAADGSKLKS NFTQDIVFTQ IPPSIAFSQQ GVFLPTNADK KISFKSMNVK KIKLKVSRIY
PNNTTAYLYD NNLIGHKSYK DNNYYDDGIY ANFHRLGDEI INEEFDISFK PNQWIQNSFD
LSALPNEGIF IIDLSFDENG VDYTFPDGTS NWRKRQFFDD ARIQKHLIFS NIALIAQHIG
DKIEVLTLDI AENKPLASVD VQAISFKNQI LAESRTDNQG IAVLKTSESI MYLSATKDSN
TTILKLNAPL SNDEFDVSGQ SIQTDTNAYI YTDRGVYRPG DSAHINIIAR ANNNPTTHPI
YLTLISPQGK EIIEKTALTD PLYGLYYYQF DIDKNAPTGI WRVKIQVGDS VFWHNLSVET
IIPNRIKVAI QAQDSIDMNK EDELTYGIQS HYLFGAKAAN LRYESNLQIM PVNFYPKSYT
DYTFNHPSSL NYSFSDSQKG QLDSEGMMQD AFTLQNVENL NKNLKAFLEA KVFENGGRSV
RAQKVIDLKL YDSFVGLKAP KTRYIDIDSN IQIPIIVLSD DEKTLIPNRN LRYRIYQNSY
SWWWDYDNYN DFVRSIKTDR NTTLIKEGEI VSKDTPIMLD FQPKTSGETL IEVQDPSNGT
NSAIFLYVSQ YGQPIEATKI QSFKIQSDKS NYLVGEEATI SFESKAHSKA LITLVDSQKV
LERFWVDAKE GQTSFKVPIK KSYAPNIYVI VNLLQNYASV DNDRSQRLYG VVPLMVEDTQ
TKLTLELKAP ESIQSNEDFT ITLSNKEHKK VAYTLAVVDE GLLDLTDFIS PNPWRYFYQK
IALTLTSFDN FNDIIGKDIG IINQILKIGG DEAGAVAKRR KDFNEAQRFK PVVLYKSPTM
SDEKGNATIK WKIPTYIGNV RIMAVAIDEN AYGSASRDMK VTLPVVMLPT IPRSLKLGDR
FSLAIEVMPT ESNIGKVDIS VKSGDKITFD KKSQSLRFTS KDAQNIVFDA QVSKDSIGTE
EIILSLTSAK FKTQEKTSID IKPNNPYTTI NKKFTIEPQG QITLSNPKDF VQNSQSGYLV
LSQKPIMSID HRLRWLIRYP YGCIEQTTSS VLPQLYLTSL SSADFIDKPS IVKNINAGIA
RIGNFQTSDG GFAYWQGGSQ ADIWGSNYAG HFLLLAKEEG YYVPQDLLKR WITYQINFVK
NQTETNTAKV YSLYLLSLAK EPQIGLLNQI YENDFDSLST SDKWLLAAAY KLAGVENIVG
KITKNLSTRV IANEHSERYY YYSYGSPLRD EAIILKAYTD IYKNSSESTQ QDRFKSLLSR
IQTLLESDDW LSTQTLGYSL LALASTSNTR NDKADAKIQV KLDGKAFESS DIRFKIPFSA
TNGNLESKNS TMLYANQVWD GILLDDNIQA SSSKIKLTQE FLNQNGEPIN VSTLPSGSTF
WIKLSVDNED QSVRTNNLAV TQNIPSGWEI ENTRLNNDIL PPFVKQQGID YTDIRDDKIM
WFFDFYGERK SVFVKINTIT PGEYILPPAT AEAMYDHSFL ANTQSSRVKV TSGVVE
//
