ID A0A4U8U8Q0_9HELI Unreviewed; 384 AA.
AC A0A4U8U8Q0;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945,
GN ECO:0000313|EMBL:TLE08225.1};
GN ORFNames=LS79_010365 {ECO:0000313|EMBL:TLE08225.1};
OS Helicobacter bilis.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=37372 {ECO:0000313|EMBL:TLE08225.1, ECO:0000313|Proteomes:UP000029857};
RN [1] {ECO:0000313|EMBL:TLE08225.1, ECO:0000313|Proteomes:UP000029857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49320 {ECO:0000313|EMBL:TLE08225.1,
RC ECO:0000313|Proteomes:UP000029857};
RX PubMed=25428971;
RA Sheh A., Shen Z., Fox J.G.;
RT "Draft genome sequences of eight enterohepatic helicobacter species
RT isolated from both laboratory and wild rodents.";
RL Genome Announc. 2:e01218-e01214(2014).
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TLE08225.1}.
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DR EMBL; JRPJ02000055; TLE08225.1; -; Genomic_DNA.
DR RefSeq; WP_034562373.1; NZ_JRPJ02000055.1.
DR AlphaFoldDB; A0A4U8U8Q0; -.
DR Proteomes; UP000029857; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR025249; KH_dom_NusA-like.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR030842; NusA_bac.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR NCBIfam; TIGR01953; NusA; 1.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF13184; KH_5; 1.
DR Pfam; PF08529; NusA_N; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription termination {ECO:0000256|HAMAP-Rule:MF_00945}.
FT DOMAIN 4..125
FT /note="Transcription factor NusA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08529"
FT DOMAIN 233..300
FT /note="KH"
FT /evidence="ECO:0000259|Pfam:PF13184"
SQ SEQUENCE 384 AA; 42629 MW; 5200B6292907A2F2 CRC64;
MEKILDIVEM IASENGLPQD QVVLAIKDSM VKMAKKEINE NANFVVIEDW GAKELRLVQK
MIVCDDSSFS KDLESTHIPL NEARSLVENV NTGDELEYQI NLEGMNRNAV NNIFHDITYQ
IQKLNEQEIL KAFEKDIGHI VIGQVAHVDD EGNTSIEIGE TRAMLSLKNR IKGEKFKVGQ
PVRSILKSVR ITKNGVKIEL SRTTPKLLEE LLMLEVPEIK DGEVSIYKIA RIPGEKAKVA
LYTNNPKIDP IGSAVGARGV RINAVSKELH GENIDCIEYS SVPEIFVAKS LSPAQVISVK
LQKADTEEEK PKAIVQIAKS QKSKAIGKAG VNIRLASMLT GYDFELQEVA DKPNEQVANK
DSIEKDEEKK LGLEALESLF KGNS
//
