ID A0A4U8V8Q2_9BURK Unreviewed; 856 AA.
AC A0A4U8V8Q2;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:TMS59531.1};
GN ORFNames=MW7_001310 {ECO:0000313|EMBL:TMS59531.1};
OS Burkholderiaceae bacterium PBA.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae.
OX NCBI_TaxID=795666 {ECO:0000313|EMBL:TMS59531.1, ECO:0000313|Proteomes:UP000004277};
RN [1] {ECO:0000313|EMBL:TMS59531.1, ECO:0000313|Proteomes:UP000004277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBA {ECO:0000313|EMBL:TMS59531.1,
RC ECO:0000313|Proteomes:UP000004277};
RA Gan H.M.;
RT "Revised genome assembly of Burkholderiaceae (previously Ralstonia) sp.
RT PBA.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TMS59531.1}.
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DR EMBL; AKCV02000006; TMS59531.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U8V8Q2; -.
DR STRING; 795666.MW7_0397; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000004277; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000004277}.
FT DOMAIN 679..695
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 605..612
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 856 AA; 93679 MW; 0ABF7F6194C0F001 CRC64;
MMQQYLRIKA EHPDTLLLYR MGDFYEVFFD DAEKAARLLD ITLTKRGASN GVPIPMAGVP
FHSLEQYLAK LVKLGESAAI CEQIGDPATS KGPVERKVVR IVTPGTLTDS ALLPDKIDTL
LLALHRTAAR RGTAAACGLA WLNLASGELR MMECPPAQLA RELERIRPAE ILLADSERQQ
MTLPATATHL PDWHFDIEAG DKRLRDQMQV ASLAAFGCDG LGAALGAAGA LLNYAANTQG
QTLRHVQSVT VERESEFIGL DTATRRNLEL TETLRGTESP TLFSLLDTCA TSMGSRLLRH
WLHHPLRDRG TPQMRQHAIA TLLTQDWQSI QAVLRQTADI ERITARLALL SARPRDLSSL
RDSLKRMPLL QQAVAPGESS LLAVLRDALP CPPACLGLLE QAIAEEPAAM VRDGGVIATG
YDAELDELRQ LSQNAGQFLI DLETRERART GIANLRVEYN RVHGFYIEVT NGQADKVPDD
YRRRQTLKNA ERYITPELKA FEDKALSAQD RALAREKLLF DELLQKLLAY IADLKRIAAA
VAQLDVLAAL AERAQTLGWN QPNLVETSTV DIVQGRHPVV ENQVEKFIAN DCQLSDVRKL
LLITGPNMGG KSTFMRQTAL IVLLAYVGAF VPAAHATIGP IDRIFTRIGA ADDLAGGRST
FMVEMTEAAS ILHNATPNSL VLMDEIGRGT STFDGLALAW AIARHLLGHN RSHCLFATHY
FELTQLPQSF PQAVNVHLSA IEHGEGIVFL HAVQEGPASQ SYGLQVAQLA GVPQPVIRAA
RKHLAWLEQH AIGSETTPQM DLFALSPAED EAPASDVEST ARHPALDALA ALDPDAMPPR
EALDALYRLK GLLEAH
//
