ID   A0A4U8VB56_9BURK        Unreviewed;       849 AA.
AC   A0A4U8VB56;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   13-SEP-2023, entry version 11.
DE   SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:TMS59560.1};
GN   ORFNames=MW7_001470 {ECO:0000313|EMBL:TMS59560.1};
OS   Burkholderiaceae bacterium PBA.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae.
OX   NCBI_TaxID=795666 {ECO:0000313|EMBL:TMS59560.1, ECO:0000313|Proteomes:UP000004277};
RN   [1] {ECO:0000313|EMBL:TMS59560.1, ECO:0000313|Proteomes:UP000004277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PBA {ECO:0000313|EMBL:TMS59560.1,
RC   ECO:0000313|Proteomes:UP000004277};
RA   Gan H.M.;
RT   "Revised genome assembly of Burkholderiaceae (previously Ralstonia) sp.
RT   PBA.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TMS59560.1}.
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DR   EMBL; AKCV02000006; TMS59560.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4U8VB56; -.
DR   STRING; 795666.MW7_0428; -.
DR   OrthoDB; 9761531at2; -.
DR   Proteomes; UP000004277; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004277};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        63..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        442..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        503..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        528..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          594..793
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   849 AA;  92024 MW;  9643AF67B8A0269F CRC64;
     MCTDRLRERV DVPAWQIGRE GGASRDVTRC KCVDDHAQEQ LSMRGLLAAF IAGNWWLQQQ
     QALSLVWPTA LCAACGMTAW LCRRRYRPVT IVAWTCCAFL GGQAWAALRA DIRLADRLDP
     GWEGRDVIVQ GAVASLPTPF ERGVRFQFDV LASTPPGVVP QRLALTRYDA PDAAASTMLA
     PLVPGDRWQL RVRLRQPVGS ANPHTFDYEY WLLEQGVRAT GYVRAGPDNR RLSEAGMRVG
     WRIERWRDAV RRHVLASMPA EAPYAGVLVA LVVGDQRGID AADWNMFNRT GIGHLISISG
     LHITMIASLF GVVVAWLWRY SFGLGRWLHR PLPLRWPARS AGIVAGIVAA ALYCLLAGMQ
     VPAQRTLIML TVVGLGFLAG RGSHRGHVLG WAAVLVVLAD PWAVCAAGFW LSFGAVALIF
     LMHPVQYAPA WGARMPRRWT GVAAAARLQW VLTVGLVPLT LLLFQQVSVV SPLANAVAIP
     VVSFIVTPLA LLGAALPEPV ATLLLAAAHT MFAWLVVILA WLGAQSWAVW QAAAPPAWAV
     LAGMAGVTLW LVPGGVASWP LRVHACVLLL PLCLVRAPRP AHGEWRITAL DVGQGTAVLV
     ETAQHRLLYD AGPAYGASSA GERVIAPYLR GLGAAHLDRL VISHEDSDHV GGAPAVLDAV
     RVSHLQAALP AGHMLWQTAT QQGTATTVCA AGQHWEWDGV RFEILHPAPG DGQRETLASN
     ARSCVLRVAN IRHAALLTGD IGLAEELQII GRSIPGHLLA DILLVPHHGS GTSSGSRFLE
     AVAPSLAIFQ MGYRNRYGHP RADVWARYGA YGVQRLRTDR AGAVMVDSAG PLLEVSAWRD
     IAPRYWHVR
//