ID A0A4V2ZQ29_9BACT Unreviewed; 943 AA.
AC A0A4V2ZQ29;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:TDF73384.1};
GN ORFNames=E0946_03220 {ECO:0000313|EMBL:TDF73384.1};
OS Candidatus Syntrophosphaera thermopropionivorans.
OC Bacteria; Candidatus Cloacimonadota; Candidatus Cloacimonadia;
OC Candidatus Cloacimonadales; Candidatus Cloacimonadaceae; Syntrophosphaera.
OX NCBI_TaxID=2593015 {ECO:0000313|EMBL:TDF73384.1, ECO:0000313|Proteomes:UP000294588};
RN [1] {ECO:0000313|EMBL:TDF73384.1, ECO:0000313|Proteomes:UP000294588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W5 {ECO:0000313|EMBL:TDF73384.1,
RC ECO:0000313|Proteomes:UP000294588};
RA Dyksma S.;
RT "Candidatus Syntrophosphaera thermopropionivorans: a novel player in
RT syntrophic propionate oxidation during anaerobic digestion.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDF73384.1}.
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DR EMBL; SMOG01000006; TDF73384.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4V2ZQ29; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000294588; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR PANTHER; PTHR43690:SF34; ZINC PROTEASE PQQL-LIKE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000294588};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 56..178
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 209..390
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 706..864
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 943 AA; 108590 MW; E90B0975D14B4EE4 CRC64;
MNLKKLIFIS VLFCALFTIL PALPNELLEQ PLQQDPAILS GQLPNGFTYY IQHNPNPSHL
AELRLYVDAG SVDEDDDQRG LAHFTEHMVF NGTKNFAKSE LVNYLSSIGM GYANGLNAMT
SYDYTIYTFK IPTDDKEKLN KGLMILSDMA YQATFDPEEI EKERGVIIEE WRMGQDAESR
IRDKQNSVIL AGSRYAERSP IGTFEVISSF TRDTLLRFYT DWYRPDLQKL VIVGDFDPQE
ILALVTQYFG VIPKPVNPRP KQEFKVPENL TPVAVVATDP EYPYNILNVM WKKEPSPVQT
YGSYLNYLKN SLFYTMLNSR LDEFSKSPNP PYSFAAAYEY PMLRTMSTAA IMSMFLPNKA
ETALTTMLTE AERVQRYGFL DSEFERAKSQ ILRELQQAVD QKETRESSQI AWELVFDLSY
NDVTLSAEQD LELTKSFLTE LTLPEINAIV TQLIQEKNMC ISIGAPEKEG LTYPSEERLL
EIAQHISTQE LEAYEDKALS APLMSHLPKP VKIKKESYDP ETGIYYWQLK NGIKIYAKKT
DFKNDEVLLS AISPGGYTRY NKEDIPAAEL VSSYLKESGF GSFDAVSLSK ATADKVVRVS
LDVGPYTETL DASCSPKDME LMFQMIYQYT TNPRFNAQDF QSFIQRTKTY YENRNLDPLN
VFMDKIDKEL YNNHPYRVNL AEVDLDKIEM STVERIFRDR FADFSDFSFI IVGNFDEILI
KQYCQIYLGN LPTKKRKEQI KDVNIYPISG QKEVRFSKGA TDRAFVSHIT NGSYKPNIEN
DVLMDGLLYV MNEKLRENIR EERSGVYLIQ AWSDMTPYPK PYYLLNIVMA CAPVRVDELN
NAIFATLDSL QSNFIDERYI ISARETLKQQ FKQNIRSNRY WINQLRTNIW LGKPLTEFTN
RPQYIDRLTP ESIVSAANSY LRFNDNKLSV IMLPENGKKD SKN
//
