ID A0A4V6HZX1_9HELI Unreviewed; 403 AA.
AC A0A4V6HZX1;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Potassium/proton antiporter {ECO:0000313|EMBL:TLD86062.1};
GN ORFNames=LS69_007090 {ECO:0000313|EMBL:TLD86062.1};
OS Helicobacter sp. MIT 05-5294.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1548150 {ECO:0000313|EMBL:TLD86062.1, ECO:0000313|Proteomes:UP000029926};
RN [1] {ECO:0000313|EMBL:TLD86062.1, ECO:0000313|Proteomes:UP000029926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 05-5294 {ECO:0000313|EMBL:TLD86062.1,
RC ECO:0000313|Proteomes:UP000029926};
RX PubMed=25428971;
RA Sheh A., Shen Z., Fox J.G.;
RT "Draft genome sequences of eight enterohepatic helicobacter species
RT isolated from both laboratory and wild rodents.";
RL Genome Announc. 2:e01218-e01214(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TLD86062.1}.
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DR EMBL; JRPA02000012; TLD86062.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4V6HZX1; -.
DR OrthoDB; 9810759at2; -.
DR Proteomes; UP000029926; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..389
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 403 AA; 44125 MW; 578F3F345D889441 CRC64;
MAEIINDLHL YIIAIGIILF ISVYASKISE KIGFPLLLVF LILGMLLGSE GIVGIKFDNT
LLAQAVGSVS LIFILYSGGL DTHWGHIKPV IVSGVMLATL GVLITAVILA GFIYLMWNVT
PLEALLLGSI VSSTDAAAVF MIFRSHRLRL KSNIEPLLEL ESGSNDPMAI FLTITILQLI
VMSGATSVME WIVQFVAQFA IGGAVGLLCG YTFPKICERL NISQPGLYPL ISVAWLFMIF
GLSMTLKGNG YLSIYIAGIL TNKFAFPYKS HIIAFHDAIA WMMQILVFLV LGLLVFPSQL
PQIALPALVL VLVLMFVARP VSVFISLANS RFNKKEKLFI SWVGLRGAVP IILATYPFVY
ELEQSHLIFD VVFFMVLVSV LVQGMTLGVA AKYLGIVDED EKS
//
