ID A0A4W2CHE6_BOBOX Unreviewed; 359 AA.
AC A0A4W2CHE6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sodium/bile acid cotransporter {ECO:0000256|PIRNR:PIRNR026166};
GN Name=SLC10A7 {ECO:0000313|Ensembl:ENSBIXP00000005723.1};
OS Bos indicus x Bos taurus (Hybrid cattle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000005723.1, ECO:0000313|Proteomes:UP000314981};
RN [1] {ECO:0000313|Proteomes:UP000314981, ECO:0000313|Proteomes:UP000429181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT "Haplotype-resolved cattle genomes.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBIXP00000005723.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Does not show transport activity towards bile acids or
CC steroid sulfates. {ECO:0000256|PIRNR:PIRNR026166}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR026166}.
CC Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR026166}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528,
CC ECO:0000256|PIRNR:PIRNR026166}.
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DR STRING; 30522.A0A4W2CHE6; -.
DR Ensembl; ENSBIXT00000005180.1; ENSBIXP00000005723.1; ENSBIXG00000001025.1.
DR Ensembl; ENSBIXT00005013095.1; ENSBIXP00005002013.1; ENSBIXG00005008458.1.
DR GeneTree; ENSGT00390000011932; -.
DR OMA; FFFYGLK; -.
DR Proteomes; UP000314981; Chromosome 17.
DR Proteomes; UP000429181; Chromosome 17.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005797; C:Golgi medial cisterna; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0034436; P:glycoprotein transport; IEA:Ensembl.
DR GO; GO:0048193; P:Golgi vesicle transport; IEA:Ensembl.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640:SF5; SODIUM_BILE ACID COTRANSPORTER 7; 1.
DR PANTHER; PTHR18640; SOLUTE CARRIER FAMILY 10 MEMBER 7; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR026166};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR026166};
KW Ion transport {ECO:0000256|PIRNR:PIRNR026166};
KW Membrane {ECO:0000256|PIRNR:PIRNR026166, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314981};
KW Sodium {ECO:0000256|PIRNR:PIRNR026166};
KW Sodium transport {ECO:0000256|PIRNR:PIRNR026166};
KW Symport {ECO:0000256|PIRNR:PIRNR026166};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR026166}.
FT TRANSMEM 41..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 359 AA; 39591 MW; B68E002C899A62B9 CRC64;
MRLLERMRKE WFMIGIVLAI AGAKLEPSIG MNGGPLKPEI TVSYIAVATI FFNSGLSLNT
EELTSALVHI KLHLFIQIFT LAFFPAAVWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVVT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP
LIIGQIVRRY IKDWLERKQP PFGAVSSSVL LMIIYTTFCD TFSNPSIDLD KFSLLLVLFI
ICSIQLSFML LTFIYSTRNN SGFTPADTVA VMFCSTHKSL TLGIPMLKIV FAGHEYLSLI
SVPLLIYHPV QILLGSVLVP TIKSWMVSRQ KKPLQTRRSP ANVDHPEVLK YLAIPSGHK
//
