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Database: UniProt
Entry: A0A4W2CIX6_BOBOX
LinkDB: A0A4W2CIX6_BOBOX
Original site: A0A4W2CIX6_BOBOX 
ID   A0A4W2CIX6_BOBOX        Unreviewed;       173 AA.
AC   A0A4W2CIX6;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Lens fiber membrane intrinsic protein {ECO:0000256|RuleBase:RU363088};
GN   Name=LIM2 {ECO:0000313|Ensembl:ENSBIXP00000011701.1};
OS   Bos indicus x Bos taurus (Hybrid cattle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000011701.1, ECO:0000313|Proteomes:UP000314981};
RN   [1] {ECO:0000313|Ensembl:ENSBIXP00000011701.1, ECO:0000313|Proteomes:UP000314981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA   Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT   "Haplotype-resolved cattle genomes.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBIXP00000011701.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Present in the thicker 16-17 nm junctions of mammalian lens
CC       fiber cells, where it may contribute to cell junctional organization.
CC       Acts as a receptor for calmodulin. May play an important role in both
CC       lens development and cataractogenesis. {ECO:0000256|RuleBase:RU363088}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU363088}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363088}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family.
CC       {ECO:0000256|ARBA:ARBA00006864, ECO:0000256|RuleBase:RU363088}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU363088}.
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DR   AlphaFoldDB; A0A4W2CIX6; -.
DR   STRING; 30522.A0A4W2CIX6; -.
DR   Ensembl; ENSBIXT00000045239.1; ENSBIXP00000011701.1; ENSBIXG00000016910.1.
DR   OMA; LFCACVG; -.
DR   Proteomes; UP000314981; Chromosome 18.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:InterPro.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR003935; LMIP.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR004032; PMP22_EMP_MP20.
DR   PANTHER; PTHR10671; EPITHELIAL MEMBRANE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10671:SF9; LENS FIBER MEMBRANE INTRINSIC PROTEIN; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01453; EPMEMFAMILY.
DR   PRINTS; PR01457; LENSMEMPROT.
DR   PROSITE; PS01221; PMP22_1; 1.
DR   PROSITE; PS01222; PMP22_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363088};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314981};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363088};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363088}.
FT   TRANSMEM        66..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363088"
FT   TRANSMEM        99..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363088"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363088"
SQ   SEQUENCE   173 AA;  19650 MW;  FB993E89195757C4 CRC64;
     MYSFMGGGLF CAWVGTILLV VATATDHWMQ YRLSGAFAHQ GLWRYCLGTK CYLQTESIAY
     WNATRAFMIL SSLCATSGII MGIVAFAQQP TFTRLSRPFS AGIMFFASTL FVLLALAIYT
     GVTVSFLGRR FGDWRFSWSY ILGWVALLMT FFAGIFYMCA YRMHECRRLS TPR
//
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