ID A0A4W2CWQ8_BOBOX Unreviewed; 1135 AA.
AC A0A4W2CWQ8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|Ensembl:ENSBIXP00005036474.1};
GN Name=SLC12A6 {ECO:0000313|Ensembl:ENSBIXP00000017861.1};
OS Bos indicus x Bos taurus (Hybrid cattle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000017861.1, ECO:0000313|Proteomes:UP000314981};
RN [1] {ECO:0000313|Proteomes:UP000314981, ECO:0000313|Proteomes:UP000429181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT "Haplotype-resolved cattle genomes.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBIXP00000017861.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR Ensembl; ENSBIXT00000030582.1; ENSBIXP00000017861.1; ENSBIXG00000021810.1.
DR Ensembl; ENSBIXT00005046929.1; ENSBIXP00005036474.1; ENSBIXG00005018176.1.
DR GeneTree; ENSGT00940000160238; -.
DR Proteomes; UP000314981; Chromosome 10.
DR Proteomes; UP000429181; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF66; SOLUTE CARRIER FAMILY 12 MEMBER 6; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000314981};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 176..348
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 467..745
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 759..877
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 891..1135
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 20..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1135 AA; 125865 MW; E0CAABEF2DC63352 CRC64;
MHPPETTTKM ASVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES VPETSRSEPM
SEMSGATTSL ATVALDQASD RTSNPQDVTE DDGHKKARNA YLNNSNYEEG DEYFDKNLAL
FEEEMDTRPK VSSLLSRLAN YTNLTQGAKE HEEAENITEG KKKPTKTPQM GTFMGVYLPC
LQNIFGVILF LRLTWVVGTA GVLQAFAIVL ICCCCTMLTA ISMSAIATNG VVPAGGSYFM
ISRALGPEFG GAVGLCFYLG TTFAAAMYIL GAIEIFLVYI VPRAAIFQSD DALKESAAML
NNMRVYGTAF LVLMVLVVFI GVRYVNKFAS LFLACVIVSI LAIYAGAIKS SFAPPHFPVC
MLGNRTLSSR HIDVCSKTKE VNNMTVPSKL WGFFCNSSQF FNATCDEYFV HNNVTSIQGI
PGLASGVITE NLWSNYLPKG EIIEKPSAKS SEVLGSLNHE YVLVDITTSF TLLVGIFFPS
VTGIMAGSNR SGDLKDAQKS IPIGTILAIL TTSFVYLSNV VLFGACIEGV VLRDKFGDAV
KGNLVVGTLS WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHSKA
NGEPTWALLL TAAIAELGIL IASLDLVAPI LSMFFLMCYL FVNLACALQT LLRTPNWRPR
FRYYHWALSF MGMSICLALM FISSWYYAIV AMVIAGMIYK YIEYQGAEKE WGDGIRGLSL
SAARFALLRL EEGPPHTKNW RPQLLVLLKL DEDLHVKHPR LLTFASQLKA GKGLTIVGSV
IVGNFLENYG EALAAEQTIK HLMEAEKVKG FSQLVVAAKL REGISHLIQS CGLGGMKHNT
VVMGWPNGWR QSEDARAWKT FIGTVRVTTA AHLALLVAKN ISFFPSNVEQ FSEGNIDVWW
IVHDGGMLML LPFLLKQHKV WRKCSIRIFT VAQLEDNSIQ MKKDLATFLY HLRIEAEVEV
VEMHDSDISA YTYERTLMME QRSQMLRHMR LSKTERDREA QLVKDRNSML RLTSIGSDED
DETETYQEKV HMTWTKDKYM ASRGQKAKSM EGFQDLLNMR PDQSNVRRMH TAVKLNEVIV
NKSHEAKLVL LNMPGPPRNP EGDENYMEFL EVLTEGLERV LLVRGGGSEV ITIYS
//
