ID A0A4W2DBV4_BOBOX Unreviewed; 1032 AA.
AC A0A4W2DBV4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSBIXP00000021679.1};
OS Bos indicus x Bos taurus (Hybrid cattle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000021679.1, ECO:0000313|Proteomes:UP000314981};
RN [1] {ECO:0000313|Ensembl:ENSBIXP00000021679.1, ECO:0000313|Proteomes:UP000314981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT "Haplotype-resolved cattle genomes.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBIXP00000021679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A4W2DBV4; -.
DR Ensembl; ENSBIXT00000036467.1; ENSBIXP00000021679.1; ENSBIXG00000024730.1.
DR Proteomes; UP000314981; Chromosome 3.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000314981}.
FT DOMAIN 46..326
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 527..722
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 751..848
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 923..1020
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 394..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 632..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 116101 MW; 20156A1C5D7C476C CRC64;
MGELEGTYRV LQTPGARLGT ATPVGVSTLE PGQGPPARAA RPAARTHIRV QLLDDSVEVF
DIEPKCDGQA LLTQVWERLN LIECDYFGLE SQNAQSCWIW LEPMKPIIRQ VRRPKNAVLR
LAVKFFPPDP GQLQEEYTRY LFALQLKRDL LEERLTCTDT TAALLASHLL QAEVGDYDEA
LDREHLRAHE YVPRQERALH RILAFHRELA GQTPAESDFQ VLEIARKLDM YGIRFHSASD
REGAKIKLAV SHTGVLVFQS STRINTFNWS RLRKLSFKRK RFLIKLHPEV HGPYQDTLEF
VLGSRDECKN FWKICVEHHT FFRLLDQPKP KAKAVLFSRG SSFRYSGRTQ KQLADYVKDG
GMKRVPYERR HSRTQMSLRA LKVDLPRQSI SFSEGVRTPV TPSPTTASFC SAPASPPVPP
GSRDFQVGSG SSETGPPAPG AWRPAAERSS MATAQPLRLP ALQPHQGLSV ESPQPSPSTQ
RSPPGLSPQG PAVQGPNPLL GPVLSDAAGA GMDDREEPKR KCVPTDEAYF IAKEILATER
TYLKDLEVIT VWFRSAVVKA DAMPADLMTL LFSNIDPIYE FHRGFLREVE QRLALWEESS
STQATGSHQR IGDILLRNML QLKALTGHFQ RLHEVLTELE AASRRLRRLE ALRRDFELQK
VCYLPLNAFL LKPLQRLRHY RLLLRRLCAP VPGHPDPHGQ DHADLRDALQ AITEVTSMLQ
HSLVQLENLQ KLTELQRDLV GIESLVAPGR ELIREGCLHK LSRKGLQQRM FFLFSDMLLY
TSRDAGGSSH FRIRGLLPLH GMLVEDQESE WSVPHCFTIY AAQKTIVVAA STRLEKAKWL
HDLNAAIDAA KTGSALVPPA RVLCPLPRGS PNEASLEPES EDEAGGAQGS VAGTGRHRAS
TAAHVCWCRQ SSVSRADHSA AVENQLSGYL LRKFKNSSGW QKLWVVFTNF CLFFYKTHQD
DHPLASLPLL GYSVSLPRDT DGIHKEHVFK LQFKSHVYFF RAESKYMFRR WMEVIERASA
SAGRAGTPEE EA
//
