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Database: UniProt
Entry: A0A4W2EF07_BOBOX
LinkDB: A0A4W2EF07_BOBOX
Original site: A0A4W2EF07_BOBOX 
ID   A0A4W2EF07_BOBOX        Unreviewed;      1020 AA.
AC   A0A4W2EF07;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN   Name=LOC113907197 {ECO:0000313|Ensembl:ENSBIXP00000035583.1};
OS   Bos indicus x Bos taurus (Hybrid cattle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000035583.1, ECO:0000313|Proteomes:UP000314981};
RN   [1] {ECO:0000313|Ensembl:ENSBIXP00000035583.1, ECO:0000313|Proteomes:UP000314981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA   Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT   "Haplotype-resolved cattle genomes.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBIXP00000035583.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC       {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR   AlphaFoldDB; A0A4W2EF07; -.
DR   STRING; 30522.A0A4W2EF07; -.
DR   Ensembl; ENSBIXT00000024818.1; ENSBIXP00000035583.1; ENSBIXG00000018877.1.
DR   OMA; RGSWDGD; -.
DR   Proteomes; UP000314981; Chromosome 17.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR031120; HIR1-like.
DR   InterPro; IPR011494; HIRA-like_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR   PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW   ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314981};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW   Repressor {ECO:0000256|RuleBase:RU364014};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364014};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364014};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          66..98
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          127..159
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          170..201
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          767..965
FT                   /note="Protein HIRA-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07569"
FT   REGION          406..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..559
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..619
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..646
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1020 AA;  111321 MW;  64DEC2D231116B40 CRC64;
     MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENVP
     KMLCQMDNHL ACVNCVRWSN GGMYLASGGD DKLIMVWKRA TYIGPSTVFG SGGKLANVEQ
     WRCVSILRSH SGDVMDVAWS PHDAWLASCS VDNTVVIWNA VKFPEILATL RGHSGLVKGL
     TWDPVGKYIA SQADDRSLKV WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA
     HAMNNSGPTA QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS AKPSCPYCCC
     AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG SVAFLDFSQD
     ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE MLQYQRRQQQ LDRQGPTARD
     AGPAARDTGS ASSVAGVVNG ESLEDIRKNL LKKQVETRTA DGRRRITPLC IAQLDTGDFS
     TAFFNSIPLS GSLAGPMLSS HSGPQLLPLD PGTPIPFSSS KPSTEPAAGT RPVGDAASKD
     GVNTATAPTT PSPSVLTTPS KIEPMKAFDS RFTERSKATP GTPALASTTP TATERLREQS
     LVKELRPRDV LESSSDSDEK APAAKPSSLP KRKLELEGEA VEKKKKGRPR KDARLLPMSL
     SMQSPAALTA EKDTVCVSVP APALKLPMPG PQRAFTLQVS SDPSMYIEVE NEVTAGGGLK
     LSRLKCSREG KEWETVLPGR ILTAAGSGDV VCVACEKRML SVFSACGRRL LPPILLPSPI
     STLHCTGPYV MALTAAATLS VWDVHRQEVV VKEESLHSIL AGSNMTVSQV LLTQHGIPVM
     NLSDGKAYCF SPSLSAWNLV SDKQDSLAQC ADFRSSLPPQ DAMLCSGPLA IVQGRASTSG
     RQAARLFSVP HVVQQETTLA YLESQVAAAL TLRSSHEYRH WLLLYARYLV NEGFEYRLRE
     ICKDLLGPVH TSTGSQWEST VVGLRKRDLL KELLPVIGQN LRFQRLFTEC QEQLDLLRDK
//
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