ID A0A4W2EUW5_BOBOX Unreviewed; 1039 AA.
AC A0A4W2EUW5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSBIXP00000040612.1};
OS Bos indicus x Bos taurus (Hybrid cattle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000040612.1, ECO:0000313|Proteomes:UP000314981};
RN [1] {ECO:0000313|Ensembl:ENSBIXP00000040612.1, ECO:0000313|Proteomes:UP000314981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT "Haplotype-resolved cattle genomes.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBIXP00000040612.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A4W2EUW5; -.
DR STRING; 30522.A0A4W2EUW5; -.
DR Ensembl; ENSBIXT00000050096.1; ENSBIXP00000040612.1; ENSBIXG00000024730.1.
DR OMA; HKHMPED; -.
DR Proteomes; UP000314981; Chromosome 3.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000314981}.
FT DOMAIN 46..326
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 527..722
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 751..855
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 930..1027
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 394..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 632..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1039 AA; 116849 MW; 429F9FE7DBACF643 CRC64;
MGELEGTYRV LQTPGARLGT ATPVGVSTLE PGQGPPARAA RPAARTHIRV QLLDDSVEVF
DIEPKCDGQA LLTQVWERLN LIECDYFGLE SQNAQSCWIW LEPMKPIIRQ VRRPKNAVLR
LAVKFFPPDP GQLQEEYTRY LFALQLKRDL LEERLTCTDT TAALLASHLL QAEVGDYDEA
LDREHLRAHE YVPRQERALH RILAFHRELA GQTPAESDFQ VLEIARKLDM YGIRFHSASD
REGAKIKLAV SHTGVLVFQS STRINTFNWS RLRKLSFKRK RFLIKLHPEV HGPYQDTLEF
VLGSRDECKN FWKICVEHHT FFRLLDQPKP KAKAVLFSRG SSFRYSGRTQ KQLADYVKDG
GMKRVPYERR HSRTQMSLRA LKVDLPRQSI SFSEGVRTPV TPSPTTASFC SAPASPPVPP
GSRDFQVGSG SSETGPPAPG AWRPAAERSS MATAQPLRLP ALQPHQGLSV ESPQPSPSTQ
RSPPGLSPQG PAVQGPNPLL GPVLSDAAGA GMDDREEPKR KCVPTDEAYF IAKEILATER
TYLKDLEVIT VWFRSAVVKA DAMPADLMTL LFSNIDPIYE FHRGFLREVE QRLALWEESS
STQATGSHQR IGDILLRNML QLKALTGHFQ RLHEVLTELE AASRRLRRLE ALRRDFELQK
VCYLPLNAFL LKPLQRLRHY RLLLRRLCAP VPGHPDPHGQ DHADLRDALQ AITEVTSMLQ
HSLVQLENLQ KLTELQRDLV GIESLVAPGR ELIREGCLHK LSRKGLQQRM FFLFSDMLLY
TSRDAGGSSH FRIRGLLPLH GMLLIVLDPP VEDQESEWSV PHCFTIYAAQ KTIVVAASTR
LEKAKWLHDL NAAIDAAKTG SALVPPARVL CPLPRGSPNE ASLEPESEDE AGGAQGSVAG
TGRHRASTAA HVCWCRQSSV SRADHSAAVE NQLSGYLLRK FKNSSGWQKL WVVFTNFCLF
FYKTHQDDHP LASLPLLGYS VSLPRDTDGI HKEHVFKLQF KSHVYFFRAE SKYMFRRWME
VIERASASAG RAGTPEEEA
//
