ID A0A4W3H208_CALMI Unreviewed; 636 AA.
AC A0A4W3H208;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=GATA zinc finger domain containing 2A {ECO:0000313|Ensembl:ENSCMIP00000009756.1};
GN Name=gatad2a {ECO:0000313|Ensembl:ENSCMIP00000009756.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000009756.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000009756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A4W3H208; -.
DR STRING; 7868.ENSCMIP00000009756; -.
DR Ensembl; ENSCMIT00000010017.1; ENSCMIP00000009756.1; ENSCMIG00000005152.1.
DR GeneTree; ENSGT00390000004097; -.
DR InParanoid; A0A4W3H208; -.
DR OMA; VWTHIAK; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.250.1650; -; 1.
DR InterPro; IPR040386; P66.
DR InterPro; IPR032346; P66_CC.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR13455:SF3; TRANSCRIPTIONAL REPRESSOR P66-ALPHA; 1.
DR PANTHER; PTHR13455; TRANSCRIPTIONAL REPRESSOR P66-RELATED; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF16563; P66_CC; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00094};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}.
FT DOMAIN 442..472
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 56..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 69595 MW; 36066BDA12F4C15B CRC64;
MAQKVMKEDA VKWRALKKHN RVKWGKPVTG LDTVSPAEAM ALQDLTEDIS AMTDDVYRTR
SQKRALEREG SNSDMESKKP KMECSPKGTE VEVDSDLEEV KKEVKIKTEP ADRGGGRTSV
LLKGSGEVKA TIKVEVQAGD EPVDMSTSKS DVKKEKRPPS PDIIVLSDNE PSSPRMNGLT
KVPGKDCNAD IMMKSTPEER ERMIKRLKEE LRLEEAKLVL LKKLRQSQIQ KEAIVPKVLT
ARTSGTVIPP PLVRGGQQMA SKMGSQQNPQ IVMPPLVRGA QPMSVSPQQI HNIRTHTSTA
PPPLLLAPRA SVPNAVQLQG QRIIPHGLIR VANVPNTSLL VNVPQASSTM KGSGGTSQSN
AGGGGLTNSN DSPASRQAAA KLALRKQLEK TLLEIPPPKP PAPELTFLPS AANNEFIYLV
GLEEVVQNLL ETQGKSSAQV VPLEPNVCTQ CKTDFTCRWR QEKTGTIMCE QCVTSNKKKA
LKAEHTNRLK AAFVKALQQE QEIEQRILQQ TASPLQSKQE SVQHHSMKQS SSQMSRGMQS
TSSRAVLHTF SQSSQLQNSV SGLGGRPAKH TERASKGGNT NWRKQIASPA GRWVTMAYVS
PSLSVHKSSS AVDRQREYLL DMIPSRSISQ SASTWK
//
