ID A0A4W3HBW9_CALMI Unreviewed; 941 AA.
AC A0A4W3HBW9;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSCMIP00000007324.1};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSCMIP00000007324.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000007324.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000007324.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A4W3HBW9; -.
DR Ensembl; ENSCMIT00000007548.1; ENSCMIP00000007324.1; ENSCMIG00000003998.1.
DR GeneTree; ENSGT00940000157711; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF162; ALHAMBRA, ISOFORM P; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 17..69
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 74..193
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 129..192
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 225..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 684..721
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 321..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 100229 MW; DC320DD915A1E5E2 CRC64;
MVSSGLPADF SNMKEMIGGC CVCSDERGWA ENPLVYCDGH GCNVAVHQAC YGIVQVPTGP
WFCRKCESQE RAARVKCELC PHKDGALKRT DNGGWAHVVC ALYIPEVQFA NVTTMEPIVL
QYVPHERFNK TCYICEEQGR ESKAATGACM TCNKHGCRQA FHVTCAQLAG LLCEEEGSEA
DNVKYCGYCK YHFSKLVIWK FSFVQIILYS IDFFVQKQKD RDKFRQKPKK SLDSSSTVPS
LTVTTEKTYT SPSSSFMPGS LKRLEETTAR FTNVNFQEVS ARPSSGNEGS EVKVLEVKGK
KTGGHSSGQR GRKPGNGKNS ACGPATGSPN SFPQGSLLGT ASSVKSPSGS SVQSPQEFQS
FTESDLRNDT CVHPQPSSTR ETIKGEIVEQ EGTLINISPL LNLPSTSSGL SQTNIENSKH
SENSHGDYGV SDATAITSSG APGFKRAQAS IMEEETIKEK KRKGSKKYKH GPGRPKGSKN
KESISQHSVS SASPSSSSVT SAAGSVASAN LQKSPSLLRN GSLQNLSVSS SPAGSGGCLS
FEHVPDTQLT KQKIRIYTSN ELPVSLQNAA PGTSCSTPIS EKILLFISNI FSLMYYGSNS
ASETNQADQE LVDTNRGLPG RSISPRASLS PRSPAGGLQI RYDPSSNNIL ENLPPVASSI
EQLLERQWSE GQQFLVEQGT PGDVMGMLKS LHQLQVENRR LEEQIKNLTA KKERLQLLNA
QLSVPFPVTS STVSPAAQMH TFSSQAVPNP ASLHSNKGSH LSNSFLPESS LPVPSQELTS
SGQSTSSSSL ASPTPIGQSP AQQGSGLIAV QKINSVTGAL ASGLQTVTST IPTMSSVGGL
MGTLSGNQMA VNGIVGALNG VIQTSESITP STLSHTAVPP NLTLPLSTSL ESTTVTLLNV
LPNCSLHELQ IIQNLAACVL SHTKLCQLTP PSPGSPSSRN S
//
