ID A0A4W3HGU5_CALMI Unreviewed; 1460 AA.
AC A0A4W3HGU5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=5'-3' exoribonuclease 1 {ECO:0000313|Ensembl:ENSCMIP00000014337.1};
GN Name=xrn1 {ECO:0000313|Ensembl:ENSCMIP00000014337.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000014337.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000014337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCMIT00000014642.1; ENSCMIP00000014337.1; ENSCMIG00000007051.1.
DR GeneTree; ENSGT00670000098080; -.
DR OMA; VASWPWF; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 2.
DR Pfam; PF03159; XRN_N; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986}.
FT DOMAIN 6..205
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 252..332
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 362..569
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 614..806
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 812..1038
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1065..1134
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1144..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1460 AA; 167282 MW; ED75F4AD572BE01B CRC64;
MGQIPEFDNL YLDMNGIIHQ CSHPNDEDVH FRISEEKIFA DIFHYVEVLF RIIKPKKTFF
MAVDGVAPRA KMNQQRGRRF RSAKEAEEKI KKALEKGEKL PTEARFDSNC ITPGTAFMAR
LQEQLKYFVN TKISTDRSWQ GVVVYLSGHE TPGEGEHKIM EFIRAEKLKP DHDPNTRHCL
YGLDADLIIL GLTSHEPNFS LLREEVRFGG KKSQRRIAAV EETTFHLLHL SLMREYIDYE
FSPIRDKICF EFDLERIIDD WILMGFLVGN DFIPHLPHLH INHDALPLLY KTYIDVLPTL
GGYINEGGTL NLEHFEKYLV KLSEFDREHF SEVFVDLKWF ESKVGTKYLN EAAGIAAEEA
RKCKKKNKIV IYEPVLDVSD IEVEDEDDLF ETEFRQYKRV YYMSKMGVEV VSDEFLAQQA
ECYVQAIQWI LHYYYHGVQS WSWYYPFHYA PYLSDIRNIR KLKIKFDIGK PFKPFEQLLA
VLPAASKDLL PKCYEYLMTD EESPIIEYYP PDFRTDLNGK AQEWEAVVLI PFIDERLLLD
AMELRNKHLS EEEKQRNKHS ECLMFCYDKE IDFNYPSLWP EKFPNIERCH ARYKLIPMNE
WHVDPSQSIM SVVDKGSLYF CGFPTLNHIK HKFFLKKTGV QVFQQPSRGE NMILEILPPK
QEEESVDDIA QQVLAKPVFV NWPHLEEARV VAVSDGETKY YLDELPGVQK VYMGKTPPPT
KVAFLRDSEQ TMWNREAQNI SESYYKRKGI TINETSVILY AQLLTGRRYV FGQNGEVTLN
KEWSKQNLPY AYQTIVKNIK AFDSSFSHFR TLEELFPSSI KVFMLGTPYY GCMGEVQDSS
DVIKDGRIRV VFNVPCEPQL DGIIQNQHKY TTKYNPGYVL ANHLGVSGYL VSRLTGSLFI
GRGSKRNPLG EQKANVGLNL KFNKKNEEVP GYTKKVGNEW LYSAAVEQIL SEYLERFPEL
FIHVAKNSQE DVFYEDNIWA GEDENGAEKV QEIVAWLKMH PVSSLSRTSC DLNVLDSAIV
EKIEDEVENC KQRKSNKKVR VTVKPHLLYR PLEQQQGVIP DQLAEYHLFD RVVNVRENFS
VPVGLRGTII GMKTAERESD ILYEVLFDEE FLGGLAMRCS PGRGYRLPKC ALINISHGSR
LEFGGQRPPP LLKPQPAPGF QHASHPSSQL ATQKVSTGGL NHSPRSPFVL TQVRFHNMDA
VTRKLLISDI LTLDSSATEN KKFNVRKTQW GVTGLCEHPV EPEDPNVLPS LILTELTREW
MFQLNVSYYL CLAAQMNKPQ GPQGGETTGQ YRGQQQPSLS TPASELLLVC ARFGLPHPEV
SFIKTPQGLI VCQVKLANGL LVHGPQCQSE SEAQEKAAVF TLQRLNATAQ NLSLPPAIFP
SYPSVAGGLP APAIPPTFSH PSGKKCLRVC SVKHFETFQR HDKTLYVESC NRVVRALASQ
VRDLGSSWAK PWGGFLTLHG
//
