ID A0A4W3I1V5_CALMI Unreviewed; 1076 AA.
AC A0A4W3I1V5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=MCF.2 cell line derived transforming sequence like {ECO:0000313|Ensembl:ENSCMIP00000021440.1};
GN Name=mcf2l {ECO:0000313|Ensembl:ENSCMIP00000021440.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000021440.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000021440.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A4W3I1V5; -.
DR Ensembl; ENSCMIT00000021825.1; ENSCMIP00000021440.1; ENSCMIG00000009639.1.
DR GeneTree; ENSGT00940000161734; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 917..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..165
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 561..741
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 753..875
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 500..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 124281 MW; B75C7338D14962F5 CRC64;
CHDYYFLQFN CAMLMVLFIS CISISGGRAE NGGPIITFPD YPSFSDIPEQ EFQSVISYLT
SVPSLQDAGI GFILLIDRRQ DKWSSVKTSL LRIVGSFPGN LQLVFVLRPS GIFQRAIFDI
VLKLNQDDFK MKVPVIMLNS VTELHSYIDK TQLTEELGGT LEYCHSQWLG HRTAIESFAV
MVKDTAQMLQ AFGTELAETE LPNDATSTMS LLTVHTEKRD KMKRDIDLAL KKGHSLLSSI
REPITKNSDY ILNADQLDHQ SNVQRLLAQL NETETAFDEF WNKHQLKLEQ CLQLRHFEHD
FREIKNTLDI LAERQNTFTD IGNSSSHVEH IMRDLCNLED KSQEYLEKAL ALILQGDELI
QNNHYAVDSI LPKCNEMRRV CDEFTNGITT KKEFLNLSMD LHKRLEKWCE SGVYLLASQP
IDKCQSQDGA EAALQEIEKF LESATDQRLD DLGRINKDYG LILNKELVAQ VQRIFQKQEA
MEEMFEKRNV SLKKLAAKQT RPVQSVAPRP EGLPRSPRSS PGTETFLLTI RLCFFMLLIE
MNEFDGRQSN SSESEENLAI LRRHVINELI ETERVYVEEL LCVLEGYAAE MENPSMILLM
PIALQNKKDV LFGNMPEIYD FHNRIFLREL ENYVEYPELV GRCFLARRGE LQIYERYCQN
KPRSESLWRQ CSDCVFFQEC QRKLEHKLGL DSYLLKPVQR ITKYHLLLKE LLKYSKNCEG
AEDLQEALTA ILGILKAVND SMHQIAITGY EGNLNELGKL LMQGSFNVWI DHKKGHAKVK
DLARFKPMQR HLFLHEKVLL FCKRREENGE GYEKAPSYSY KHSLNMTTVG ITENVKGDHK
KFEIWYNARE EVYIVQAATQ EIKNTWINEI RKILTGQLQC NHLIDLFCWI NDFTTGEKLK
WELMTTMQFF NHLSQTMLLF CCAILYLTSF IYVAGWNRTS HSLDATEENN DGWSSADDQL
NSSDGEEETG KKMFPGKYTV LSDYEKGGTD EFSVRSGDML QLIREGEEGQ WYVYSRDLFK
QIGPWCNISS KVLPQCCIEV SGKFIKLKSF LCEAKEYLRG TVHLPLRFLF ANLLFV
//
