ID A0A4W3IIR8_CALMI Unreviewed; 742 AA.
AC A0A4W3IIR8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=EF-hand domain-containing family member C2 {ECO:0000256|ARBA:ARBA00039880};
GN Name=efhc2 {ECO:0000313|Ensembl:ENSCMIP00000026603.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000026603.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000026603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000256|ARBA:ARBA00035003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR RefSeq; XP_007899859.1; XM_007901668.1.
DR AlphaFoldDB; A0A4W3IIR8; -.
DR Ensembl; ENSCMIT00000027033.1; ENSCMIP00000026603.1; ENSCMIG00000011637.1.
DR GeneTree; ENSGT00530000063528; -.
DR OMA; RFSCKQP; -.
DR OrthoDB; 160134at2759; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF11; EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986}.
FT DOMAIN 75..182
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 226..366
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 427..535
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
SQ SEQUENCE 742 AA; 85911 MW; 27051D46660480B4 CRC64;
MTLPLLPGNT FNRNLGKEKF HKSHHFDFPN GVPTIVGDEK PGIGGEPLVG QKLKIRHSVF
PKGQGTDAPA WVAFDKQVLN FQAYFQEAVQ EKREERYRIR KVKIYFYLED DTIQVIEPEV
KNSGIPQGTL IRRHRIPLPF PNEDMYYTVD HFNINQEIVF YSRTFMITDC DAFTKNFLRK
MGARVNPPAC VPEDPYNEKR EELRKNMQPL RPYEKLDTLR QFLDHDTHVL RFYGYWDDSE
TMFGDLRELV LHYYLADDTI EIREVILPNS GRDAVSIFLH RSRLPKHVPE RLPHPGEITD
HTILNVFGQM GHAGRYILDG LKTGAVYQEM YKDSDLMIGA VINVWGRKVV ICDCDEFTKE
YYRNKYGIAE FTPIKIKSKE GPKIEKEIAP YTGFGSEEDS LNSTLKMVPH VQRNMLKFME
NDRQGLDGNV LRFSARMVLD SNPINSERKF VISYFLNDDT MSIFEPPISN SGVVGGKFLE
RGKIKKPNQE LFKSEPSQYF TVHDLFIGAK LCLNGHSFLL VDADEYTLCY MEKHADEFLK
GNICSILSKL KTINNDKSLE IKRMFAAQDF GSCGIIRYDQ FRDILLEIAQ EHFTPHEIMT
ICRYYSIREQ PGSDLCVVLA LVQEQLRKHP FEDFTKLTQA FTFEDQQRTG LLSTKESRNI
LKSFHLPLSK DLIEELLSKF KDAEGRVQYT NLISSMNWRE YPLPASEVAQ YPSKGWNGEP
PTQPVKVINY IALIEDLFGK QE
//
