ID A0A4W3IYV7_CALMI Unreviewed; 942 AA.
AC A0A4W3IYV7;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Nardilysin convertase {ECO:0000313|Ensembl:ENSCMIP00000025800.1};
GN Name=nrdc {ECO:0000313|Ensembl:ENSCMIP00000025800.1};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000025800.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000025800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR AlphaFoldDB; A0A4W3IYV7; -.
DR Ensembl; ENSCMIT00000026225.1; ENSCMIP00000025800.1; ENSCMIG00000011157.1.
DR GeneTree; ENSGT00940000155026; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 88..216
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 269..357
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 379..660
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 708..812
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 40..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..72
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 108525 MW; 752A75AB20EAC908 CRC64;
MIHNRSDADI VKSPNDPKEY RYIKLENGLS ALLISDMSIG TKRTDSESLS EEEDSEDYSE
SSGSDSAEDS IEEFEDPGRP FNIPKGAEKQ SAAGLCIGIG SFSDPEDLPG LAHFLEHMVF
MGSEKFPDED GFDAFLKKHG GSDNASTDCE TTVFQFDIQR KYFKEALDRW AQFFIGPLMI
RDTIDREVEA VDSEFQLAIP SDSSRKEVLF GSLAKPGHPM SKFFWGNSQT LKHNPKQQGI
DVHARLQEFW KRHYSAHYIT LAVQSKVVPV TKVHSLNITW ALPPQKQHYR VKPLQYISWL
IGHEGKGSIL SLLRKMCLAL ALFAGNDETG FEQNSTYSVF NISITLTDEG YEQFYEVKTS
IICFSRIYEE IQKIEDNDFH YQEQTDPIDY VEDICENMQL YKKEDFLTGN QLLFEYKPEV
IATALSYLKP QRANLILLSP NNEGQCNLKE QWFGTQYSVE DVVKRWAEIW KGDFTLNAEL
HLPVENKFIA TDFALKNSDC TDTEYPVKVL GKEYGCVWYK KDNKFKIPKG YIRFHLISPL
IQESPENLVL FDLFVNILAH NLAEPAYEAD VAQLEYSLLA EEHGLVIKVK GFNHKLELLF
QLIIDHLAQF TTTPEVFAMI TEQLKKSYFN ILIKPEKLGK EIRLLILEHG HWSLMEKYQA
LMNASTTVET LTSFVKKFKQ ELFIEGLVQG NFTSKIVKRL QTILHLVELP QKAYICKVKS
LNKGDANSEV TVYYQMHMDE PCFDCLRTKE TLGYNVYPTC RNTSGIVGFS VTVETQATKY
STEYVDKKIE EFLFSFYKRL QNMNQDAFHS QVTALIKLKQ CEDIHLGEEV DRNWAEIFTQ
QYLFDRLNHE IQALKSFTKN DLVQWFKAHR GKNSRKLSIH VVGFGQHEYE DHDKGLNESL
YGEVSQLTFL PISKLMENSL PINNFQSFTE TLNLFPFHKI LK
//
