ID A0A4W3JYE4_CALMI Unreviewed; 3351 AA.
AC A0A4W3JYE4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Polycystic kidney disease 1a {ECO:0008006|Google:ProtNLM};
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000043248.1, ECO:0000313|Proteomes:UP000314986};
RN [1] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17185593; DOI=10.1126/science.1130708;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Ancient noncoding elements conserved in the human genome.";
RL Science 314:1892-1892(2006).
RN [2] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17407382;
RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA Brenner S.;
RT "Survey sequencing and comparative analysis of the elephant shark
RT (Callorhinchus milii) genome.";
RL PLoS Biol. 5:E101-E101(2007).
RN [3] {ECO:0000313|Proteomes:UP000314986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24402279; DOI=10.1038/nature12826;
RG International Elephant Shark Genome Sequencing Consortium;
RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA Wilson R.K., Brenner S., Warren W.C.;
RT "Elephant shark genome provides unique insights into gnathostome
RT evolution.";
RL Nature 505:174-179(2014).
RN [4] {ECO:0000313|Ensembl:ENSCMIP00000043248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR Ensembl; ENSCMIT00000043871.1; ENSCMIP00000043248.1; ENSCMIG00000017950.1.
DR GeneTree; ENSGT00940000158702; -.
DR OMA; VKFTWVI; -.
DR Proteomes; UP000314986; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00146; PKD; 6.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR46730:SF1; PLAT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF00801; PKD; 10.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00089; PKD; 12.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 10.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 9.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2546..2566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2752..2773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2793..2814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2874..2900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2906..2924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3146..3169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..116
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 131..195
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 258..356
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 676..750
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 771..827
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 849..919
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 917..1007
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1033..1093
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1290..1352
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1380..1435
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1611..1685
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1696..2203
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 2589..2703
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 3218..3251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3220..3251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3351 AA; 369826 MW; 83B2436CBF57F077 CRC64;
MIVGSSRYLR ETNLLLCFAA DHFVSCVGDR ASAWDPAMIY SSIDPSAHNR RSCHAACRRG
GHTRYSLDVR GYCLCGSPRG RTSPSPETAR CSSVCSNPVP ARACGRSVVR SVYEVRLGLM
ATGRCVYSLY EPVVLTLAGS GLISRYMWDF GDGSVAWNTS SRSAQYKYGL PGRYWVRVQA
FTSFEVLSLS QELVVIMVID GRVGLQCPGL VEAGGSVDIW LQTWQGTQMS AEWRVTSSNG
HEETGEDLVL FPPIFPLTNG HCYWLSQVKE SWRRAQQLCQ QTPGTDLVSV NHQDVQNFIQ
QKDVTVYPDD VIGIQHDAGP GCLLGCQSSS KSPWRQSYIS LEQQSWVEMS LTGFQPAWLS
AKWVDSVVCD VRVLYTEELR SFAVTPLLST GQTQAGTYTY SVTVANKVSS VTQSCRVEVR
SKITGLQIIF PRPLHGRLQV PTNSSTVVVI KILSGSNATA SWGVPIRRSG VRFESGCPPD
VPRFAPACRR ETGDTWFAHA HLTPTDRRLR TLSVAVSNDI SSQNLSVLVQ AHDAIGGLRI
VPPGPRRMLV DLFSPAVTRG TSVTYTWVID DLTVFAYTGQ TYIIFPWASV VCVCVFVRLC
VCACVCVCVC ACQPHGTLTG TGNLKIFSSA LGDYNLEVET RNRWAFTKKC LSVYARSPLS
DLKCVQTPEF PYIDGNVDFE AFPHPSPFGI TYTWDFNDQS PHPVTVGRNS TVQHRFQRSG
VYNVTLWANN TISAISTHVL VSVVERISGL AVSTNGPNEL GVATLVKGKV SQGTNIVWSF
DMGDGYIFRN LPKSNVSYIY AAEGNYKVTV SSSNMVNSVN RSVDVNVYAL RIMEVMPSGC
LVSGQNSFFK ARISGSQNNI KFSWNFGDGG PTVGIQGNSS IVHAYSLAGN YTIRINVSSP
FNTAYSQAGV CIESLIDSVQ LVASNKSVRL NELVQFIAEV VPSEDNQHQY TYLWDFGIGE
SPILGNGAVS SLYKEVGVYL ATVCVSNRID SKSESCSVVV QESVGKFSVS HDGSNQTTLS
LNKTYRFKLD VVSGTNVTFT WDFGDDTSAR LGQNPSHAYS NSGVFTVSAI GTNLVSRMES
YLNVMVLTPI TELKINTNRL IVEIGKEVTF TATLSGGDQV CFFWAVCRGC IRQEGTSLFK
HRFQGLGIYD VLLTARNYVS EERDMISLQA QEKMLDLEIY SEDLVQDSYC ATKEDCKLLA
RVASGSNMTY GWLISQGPAT RLRGRGSSMV FHPEAAGDYL AIVLAENGLG AVNQSKRIFV
QERISGVKVT GTAESVAIGI PVNLSVSVIS GTDLLYQWFL GTDENILTTS ISSISYIYLS
LGTVVVNVTV SNVLGSADGS MALRVQEAVS RVSYTLLRAV PPFYVPSNAT ARYQGHAGRG
SDITWQWSLP EDMGSEVLNG SEITYTFKRA SVYPLTLNAS NEVSWESVSH NITVQDCVRG
LMIRADKAVA RVGDPVIFTI SVQRGTSVWY SLYFPTFNVS VFLQGDTYEM VFPAVGENTV
TATAWNNVSS EVKFTRIVVV EEITGLHWVS CCPAAVEVNK ERTFTAEVRA GLEVIYRWDF
QLPGSTDYHL SGQSVSYTPH REGALTVHVK ASNAYSTLSL MEVIRVQFPV AEAELWSNGT
DLYVNQTVMF RVTIAGGSDV YYRWSFGNSQ NVYVNQNSTA LYHYTTPDDY AVEVTAYNNI
SFFVTRLGVT VRKPECVMPE VQLVEPPHTI FRARVNYFEA SVDLKGCTLY KTHYLWEAFR
ASSCEEAQAV DRVFLGNVDT SKPLLVLPKL LLNTSTYCLQ FTVSLHRTPL LRSVSFRIRV
LQSKLVPVIG GGSRRAWAAS QDLLLAGSKS YDPDTKTSEE ACCCCLQILS SPPCLSPASQ
TKATLTIPRK TLLPGNTYVF TLTVSKWGKE AASVLIQAER VPCVLLECIS CNALSSYRVS
RSIHVTLAGQ CENCSSNTSH KWTVQSSDGF PLTLDNQTTS TGDSNPDLVI RQGVLRNGVN
YTFTLSVMDP EKHSSGFSSI MLTPNYPPSG GVCTVKPDTV FYLLETVISV NCTGWLDEDG
GFDQLIYSLI AMSCLDRSDA CHQYHLYRGI RSSFSALVPA GTQGNTSAVS IVVEVEDLLG
AKTTAVNRTL TVLMPELPSG FQNVTDWLKS KSQRELWGLV QQGNPNQVIP YSIALLSNNG
VSEQDVYERI SIRSNVTLAL TSLHLTTVED VTQLSAAMAQ CAVCNQLLPR LLTPSGTDPC
LATETSFLLC AGGALAAVDG SQEDVEPPAG GGITSASVFQ LTNQLMKSLM RSRVLNEEPL
SLSASGIEVH GKRTNPLNLL CARFGRGCPF HVPDALSGQL SGHREVVQVL MNIGVNPFLA
GSIGHYSVST RVASMEFTTP GGTRIPINDL PGDQSIQVIL ANNSARRPGH SSTAMSIVAG
GWVNFTVRPV NSNRAAGLHI QLTLTAYPEA RRWVSAPWIV WLTALMCCIP AYSRLYDTTA
PYNINVSSRF SSVPVNVSVT VYTSLCQYFD LEQLRWRTNG MVSTHRTTPG EAVCLTRHLT
VFGASMFVSP DAVEFLPPAD RPAQNLIVVI TCALVFAVYV VMALIAHKLD HIDINSVGIV
PVCGQHGRYK YGIMVKTGWC KNSGTTAHVG ISLYGLNKSG SRHLGKEGAF QRNSLDVFQI
ETDTILGEIW KIRIWHDNTG LDPSWHLEHV IVWDKQTDSM YFFLVRDWLS VENEKNEGMV
EKEVLAACEY PTLRSFSRIF LSQLKRGMSE KHIWLSVWDR LPRSRFTRVQ RVTCCTLLLY
LFLAAVTAWY GAVGVKSKRV PVVYLASVTG ENVAVGIVVA LVVFPVHLLF TLLFRRTRSK
VRIGASREMC PDLHVWNSVV RRAAGTDAVM SANKCLPFGT GVSKSPKKWL FPHWVLYVTY
LVCFLLIAAS VGVTVTYGRL FHNNVVLMWL ISAFSSFLTL FFVLEPIKVL CEALLLALVT
KPVDPDEDDN LVEEPLIKKM SEKISKVRPP YGYGLLQAKE EARKVRALHT IMKVREILTK
AQHRRSMGLY DSGGYTQELG NNFGESSSIL WDLRKNNWID PMTRAVFVEF TQYNHNVDLH
VVLTLLLEFP AVGSVASTVD IKPITMMRSS QGANLQLVMM VSAESKPYNC TCVCALSSDE
HYSLLRGLVT LQRAVQQYPA SGSIYFISYL ACLLWIMARL FSAIIIHSYK VVRVEMYRPA
IEPQDYEMIE FFIKRFKLWI GLSKAKEFRH KVKFDGMESL PSRSSRNSKL SRFPSVSADS
HYSDSSISSG SMRSVDLNIP ESPAGVAYDV QLYLDRLLPT VNSLLGQFDR VNKVTYDLYQ
IEAGLESVQC KINTRKQSQV SREMVNVQKR MNHPATMQLV LPRTYSTESH H
//
