ID   A0A4W4EGY8_ELEEL        Unreviewed;       631 AA.
AC   A0A4W4EGY8;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=ENTH domain-containing protein {ECO:0000259|PROSITE:PS50942};
GN   Name=si:ch211-200p22.4 {ECO:0000313|Ensembl:ENSEEEP00000010628.1};
OS   Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC   Gymnotoidei; Gymnotidae; Electrophorus.
OX   NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000010628.1, ECO:0000313|Proteomes:UP000314983};
RN   [1] {ECO:0000313|Proteomes:UP000314983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24970089;
RA   Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA   Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA   Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT   "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT   organs.";
RL   Science 344:1522-1525(2014).
RN   [2] {ECO:0000313|Proteomes:UP000314983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28695212;
RA   Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT   "A tail of two voltages: Proteomic comparison of the three electric organs
RT   of the electric eel.";
RL   Sci. Adv. 3:e1700523-e1700523(2017).
RN   [3] {ECO:0000313|Ensembl:ENSEEEP00000010628.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC       {ECO:0000256|ARBA:ARBA00008011}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A4W4EGY8; -.
DR   Ensembl; ENSEEET00000010751.1; ENSEEEP00000010628.1; ENSEEEG00000005373.1.
DR   GeneTree; ENSGT00950000183068; -.
DR   Proteomes; UP000314983; Unassembled WGS sequence.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   CDD; cd16985; ANTH_N_AP180; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.58.150; ANTH domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR   PANTHER; PTHR22951:SF11; ENTH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF89009; GAT-like domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314983}.
FT   DOMAIN          14..145
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   REGION          525..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          318..348
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        536..557
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  69029 MW;  B302C015EF3604EE CRC64;
     MSGQSITDRI AAAQHSMTGS AIGKAVCKAT THEVSGPKKK HLDYLIHCTN EMNVNVPQLA
     DTLFERTANS SWVVVFKALI TTHHLMMYGN ERFIQYLASR NTLFNLNNFV DKGALQGYDM
     STFIRRYSRY LNEKALSYRL VAVDFTKMKR GVDGVMRTMN TEKLIKTLPI IQNQLDALLD
     FQANPNELTN GVINAAFMLL FKDSIRLFAA YNEGVINLLE KYFDMKKNQC KDALDIYKKF
     LYRMTKLSEF LKVAEQVGID QGDIPDLTQA PSSLLEALEQ HLASLEGKKT KEFSADSRAT
     TLSSAVSSLS STGMSFSRVD ERERQQALEE EQARLQALKD QRLKEMNVQT PTASPAALPV
     SSATNHKSSL HRNVVKLLDC FLLVSHSMAH LASDLFDVQP AFIPAMQSAP SISTATSAWG
     GRVALCQDTQ LLHGAAALPE ALASLSGAPQ QAAHIPAMNV DFDAVFGSQA ARFDVLGDLL
     KPTLPAHSQG PVMAPPTGGK LLANDLDSSL ANLVGNLHFG GSAVKKPDMQ WTQPGEKKLT
     GGSNWQSKTM SSTTAWSPAP MPPTPAPMAF PMTTPQVPVY GMVSVPVMTP QPVLYNQPVL
     RPTNPFAPIP GAQTSALADL IYLFNFMPKE M
//