ID A0A4W4F7E8_ELEEL Unreviewed; 836 AA.
AC A0A4W4F7E8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN Name=xrn2 {ECO:0000313|Ensembl:ENSEEEP00000019623.1};
OS Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC Gymnotoidei; Gymnotidae; Electrophorus.
OX NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000019623.1, ECO:0000313|Proteomes:UP000314983};
RN [1] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24970089;
RA Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT organs.";
RL Science 344:1522-1525(2014).
RN [2] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28695212;
RA Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT "A tail of two voltages: Proteomic comparison of the three electric organs
RT of the electric eel.";
RL Sci. Adv. 3:e1700523-e1700523(2017).
RN [3] {ECO:0000313|Ensembl:ENSEEEP00000019623.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. May promote
CC termination of transcription by RNA polymerase II.
CC {ECO:0000256|PIRNR:PIRNR037239}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC ECO:0000256|PIRNR:PIRNR037239}.
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DR AlphaFoldDB; A0A4W4F7E8; -.
DR Ensembl; ENSEEET00000019838.1; ENSEEEP00000019623.1; ENSEEEG00000009608.1.
DR GeneTree; ENSGT00670000098098; -.
DR Proteomes; UP000314983; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 2.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR037239};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW Reference proteome {ECO:0000313|Proteomes:UP000314983};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00047}.
FT DOMAIN 263..276
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 816..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 836 AA; 95826 MW; 5DD341AEEF1A511E CRC64;
MGVPAFFRWL SRKYPSIIVH CVEEKSKECN GVRIPVDTSK PNPNEVEFDN LYLDMNGIIH
PCTHPEDKPA PKNEDEMMVA IFEYIDRLFN IIRPRRVLYM AIDGVAPRAK MNQQRSRRFR
ASKEGMELTE EKHRMREEVL QRGGYLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD
RLTNDPGWRT LSVFLSDASV PGEGEHKIMD FIRRQRAQPN HDPNTHHCLC GADADLIMLG
LATHEPNFTI IREEFKPNKP KPCALCGQMG HEIKDCQGVA REKRGEHDEF ADTVPVSEQE
FIFIRLCVLR EYLQRELTMA SLPFPFNFER SVDDWVFMCF FVGNDFLPHL PSLEIRSGAI
DRLVSIYKDV VHRTGGYLTE NGFVNLERVE LIMQAVGVAE DNIFKKRKED EENFKRRMKE
KKKRLKAPAF LPGGQFAPQA LGGRDRPMAV QNARQTAFDM RMQGSLVSPS SDGAGCSDGV
DRLGVKRKAE DSDSEPEPED NVRLWEEGWK QRYYKTKFDV DETDDDFRKK VVKSYVEGLC
WVLRYYYQGC ASWKWYFPFH YAPFASDFKD IKDMFMEFEK GTKPFSPLEQ LMGVFPAASG
NFLPPTWRAL MTDPDSSIID FYPDDFAIDL NGKKYAWQGV ALLPFVDERR LRASLEKVYP
DLTSEEVRRN SLGSDVVFVS KSHPLCDFIQ ELYRSESHEV CNIALFPSCP KAPSFCSPCQ
SGGIKFKDPQ YEEGHVFKAV ILPGAKIPSK VLKPGDWEKS SSGPWRPQLG FNPNRHQVHL
DQSAFRSSTR KWSACSRPTL CWQARGWSVQ QCPASQLISP GKLPPTPQRP SSALPA
//
