ID   A0A4W4HBG4_ELEEL        Unreviewed;       978 AA.
AC   A0A4W4HBG4;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSEEEP00000045925.1};
GN   Name=HIP1R {ECO:0000313|Ensembl:ENSEEEP00000045925.1};
OS   Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC   Gymnotoidei; Gymnotidae; Electrophorus.
OX   NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000045925.1, ECO:0000313|Proteomes:UP000314983};
RN   [1] {ECO:0000313|Proteomes:UP000314983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24970089;
RA   Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA   Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA   Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT   "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT   organs.";
RL   Science 344:1522-1525(2014).
RN   [2] {ECO:0000313|Proteomes:UP000314983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28695212;
RA   Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT   "A tail of two voltages: Proteomic comparison of the three electric organs
RT   of the electric eel.";
RL   Sci. Adv. 3:e1700523-e1700523(2017).
RN   [3] {ECO:0000313|Ensembl:ENSEEEP00000045925.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   AlphaFoldDB; A0A4W4HBG4; -.
DR   Ensembl; ENSEEET00000046433.1; ENSEEEP00000045925.1; ENSEEEG00000021642.1.
DR   GeneTree; ENSGT00940000153594; -.
DR   Proteomes; UP000314983; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314983}.
FT   DOMAIN          702..943
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   COILED          322..356
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          419..544
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   978 AA;  110236 MW;  C8932869C204AB27 CRC64;
     MLTYFLFPQL QSIGKCMTPT EAPIKEKYAR TILLGTHKEG GAVTFWSHAV SLPLASSAIV
     SWKFCHLLHK VLRDGHPNVS ARKPLSAVWL GTLHDRYGHI VALYAKYLCI KIEFHCKVSL
     CEIMQNASLY IKGMTSVACD MHFKVLGVFS VMWVLLLYFC ARDAVFRQLE SNSTSSATPV
     GQCRLSPLVP VIQDCGPLYH FLVKLLFKLH SRIPVDALLG HRERFRDQFN RKKVFLKNNL
     QYLHLKKGLV VQNLEQLEDD DTETQVDFGE GLGYQMSLIF CILVQDFHSG FHGHFVHVLR
     DTEVVSLRKE LEAVKPELHI FKAEAQRAVV HLKEQVNKLE AELEDQRTQK QMAMVENECL
     RMEVETLRTQ NAVTKMINNR PRDRTISFSR LKEKHAELVS RHADLMRKNA DTVKQLASTQ
     QAQEEVVRAK EQMAVELEQL KQEKSMKLEA HKAEIVKLKQ ELQTGKAEIT QVQSALQSKE
     KTGDQLSSVL VGLQAEKEAL LRSVREQEAE LSSLRQSAHQ HQEREKTQRE MGALQIQLQA
     KSSQEYLLQQ KLQEEQFCLL QCAVVEAEGI ILDAVAKVDD PMHVCCVCTP EYLINRAETT
     LVSIDKMQQN HAVYLSNMEG KAPPAKPCSM FFHWPMGVSS TCHMIFPPSR RLTDSCRDCA
     THCLQFLREL KLKATLPKAD PTAIRYVIQR ILSQGQNLRH TDQDAQKAEL ADLVDMEMTA
     TSTAIEDAVL RMDEILNQAK RDTSGIKLEV NQRLSRCNLC FPQAIHMLIT AATDLQKDVV
     ESGRGAGSAK DFYAKNSCWT EGLISASKAV GWGASRMVES ADKVVTDQGK YEELIVCSHE
     IAASTAQLVA ASKVKADRGN KKLHTLQQAS RHVNDMAAVV VTSTKTGQMQ IEYKDPLDFS
     GISLIKLKTE EMDSQVRVLE LESQLCQERQ RLGELRKRHY ELAGLSPDQP EEGDFSGFVS
     VLPPVVFGAT KVPSVAQK
//