GenomeNet

Database: UniProt
Entry: A0A4W4HCB5_ELEEL
LinkDB: A0A4W4HCB5_ELEEL
Original site: A0A4W4HCB5_ELEEL 
ID   A0A4W4HCB5_ELEEL        Unreviewed;       223 AA.
AC   A0A4W4HCB5;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
GN   Name=cldn15lb {ECO:0000313|Ensembl:ENSEEEP00000046498.1};
OS   Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC   Gymnotoidei; Gymnotidae; Electrophorus.
OX   NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000046498.1, ECO:0000313|Proteomes:UP000314983};
RN   [1] {ECO:0000313|Proteomes:UP000314983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24970089;
RA   Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA   Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA   Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT   "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT   organs.";
RL   Science 344:1522-1525(2014).
RN   [2] {ECO:0000313|Proteomes:UP000314983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28695212;
RA   Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT   "A tail of two voltages: Proteomic comparison of the three electric organs
RT   of the electric eel.";
RL   Sci. Adv. 3:e1700523-e1700523(2017).
RN   [3] {ECO:0000313|Ensembl:ENSEEEP00000046498.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000256|RuleBase:RU060637}. Cell membrane
CC       {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU060637}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|ARBA:ARBA00008295, ECO:0000256|RuleBase:RU060637}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU060637}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A4W4HCB5; -.
DR   Ensembl; ENSEEET00000047008.1; ENSEEEP00000046498.1; ENSEEEG00000021887.1.
DR   GeneTree; ENSGT00940000157650; -.
DR   Proteomes; UP000314983; Unassembled WGS sequence.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   PANTHER; PTHR12002:SF171; CLAUDIN; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW   ECO:0000256|RuleBase:RU060637};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU060637};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314983};
KW   Tight junction {ECO:0000256|ARBA:ARBA00022427,
KW   ECO:0000256|RuleBase:RU060637};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU060637};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU060637}.
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU060637"
FT   TRANSMEM        121..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU060637"
FT   TRANSMEM        160..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU060637"
SQ   SEQUENCE   223 AA;  23959 MW;  4BE931BB3512C3F7 CRC64;
     MSMGTELLGF LLCVGGWLLT AVSLANNYWR VTSFAGSVIT STRQYQNLWQ ACAEASTGIR
     NCRRFESLLA LEGYVQTSRA LMIIALLLGL ASILLSVLGL KCTKMGSMTE QAKGKLTFTA
     GLLFILSGVC VLTAVTLYAA RIVQEFNDPF YIGTKFELGA GLYLGWAAAA LVILGGGMLC
     GSFRRASTPR NKSGYSYNYT AGQGQQIYKA PSSSENNSSK AYV
//
DBGET integrated database retrieval system