ID A0A4W4HCW6_ELEEL Unreviewed; 939 AA.
AC A0A4W4HCW6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ubiquitin like modifier activating enzyme 6 {ECO:0000313|Ensembl:ENSEEEP00000046747.1};
GN Name=UBA6 {ECO:0000313|Ensembl:ENSEEEP00000046747.1};
OS Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC Gymnotoidei; Gymnotidae; Electrophorus.
OX NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000046747.1, ECO:0000313|Proteomes:UP000314983};
RN [1] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24970089;
RA Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT organs.";
RL Science 344:1522-1525(2014).
RN [2] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28695212;
RA Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT "A tail of two voltages: Proteomic comparison of the three electric organs
RT of the electric eel.";
RL Sci. Adv. 3:e1700523-e1700523(2017).
RN [3] {ECO:0000313|Ensembl:ENSEEEP00000046747.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR Ensembl; ENSEEET00000047259.1; ENSEEEP00000046747.1; ENSEEEG00000021839.1.
DR GeneTree; ENSGT00940000158826; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000314983; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF186; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000314983}.
FT DOMAIN 809..931
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 939 AA; 105331 MW; 6EDF8895F6CA766F CRC64;
NMADSMEIDD SLYSRQRYVL GDSAMHQMAQ SSVFLSGMGT LGTCKIPPPH LSCRVEAVHS
RVAELNPYVQ VNSSTVALDD ITDLSFLLQY QCVVLTETSL NLQKRIDHFC HSHTPPVHFL
LNILLWDVNG FLLLPATSPC PIKENPGVVM CLDNRMHGLQ TGQSVCFREV NGMTELNGTT
HQIKVLSPYS FAIGDTSSFQ SYLHGGILRT VRVPRTFHFA TMEQQLHDPK LLIPDFSKPE
VPLQIHTTMM ALDLFQEHHS RLPIAGCVQD SEDLLKLVEE VNETLKSKAC MNAALVRCVL
RCARGCLAPL AAAVGGIASQ EVLKALTGKF MPLQQWFYLD ALEVVQPLQT LPLEEFASRG
DRYDALRVCI GESLLSELHK LRVFMVGCGA IGCEMLKNFA LLGVGLARCS GEICITDPDL
IEKSNLNRQF LFRPQHIQVI YSFIPLRQRL AXLNKVCPAT EDAYNDTFYS QLSVVVTALD
NVEARRYLDS RCVSNQKALL DSGTMGTKGH TEIIVPNLTE SYNSHRDPPE EEIPFCTLKS
FPAVIEHTIQ WARDKFESAF SHKPSMYNTF WQSHLSTEDV LHVSAGESMD GAFQVIKLLS
RRPARWEHCL ALARLKFDKY FKRKALQLLH SFPLDTRLKD GTLFWQSPKR PPNPIEFDIK
DPLHFGFLVS TARLFAGIYN VPYTEKRIET DETVKKPDQM KLTVSSAEER EAISQLEEAI
TTGFVTQECL RMSPLVFEKD DDSNGHMDFV EAAATLRARM YAIAPADRLQ AKRIAGKIIP
AIATATAAVA GLVALELIKV AGAYGFESFK NCFFNLALPV VVLTETAQVK RTRIRDDISF
SIWERWSIVG HEDFTLSDFL SAVREKYGIE PTMVVHGVKM LYVPVMPGHS KRLKLTMQKL
VKPSANRKYV DLTVSFAPEA DGDEDLPGPP IRYHFCNRA
//
