ID A0A4W4HLY4_ELEEL Unreviewed; 1002 AA.
AC A0A4W4HLY4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Solute carrier family 12 member 7a {ECO:0008006|Google:ProtNLM};
GN Name=LOC113574707 {ECO:0000313|Ensembl:ENSEEEP00000049651.1};
OS Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC Gymnotoidei; Gymnotidae; Electrophorus.
OX NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000049651.1, ECO:0000313|Proteomes:UP000314983};
RN [1] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24970089;
RA Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT organs.";
RL Science 344:1522-1525(2014).
RN [2] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28695212;
RA Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT "A tail of two voltages: Proteomic comparison of the three electric organs
RT of the electric eel.";
RL Sci. Adv. 3:e1700523-e1700523(2017).
RN [3] {ECO:0000313|Ensembl:ENSEEEP00000049651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A4W4HLY4; -.
DR Ensembl; ENSEEET00000050195.1; ENSEEEP00000049651.1; ENSEEEG00000022118.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000314983; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000314983};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..220
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 341..613
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 631..745
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 746..1002
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 877..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 111733 MW; 43E19BEA003BFB1D CRC64;
MALFEEEMDS TPMVSSLLNK LANYTNLTQG VADHEEAESE DGIKRVTGPQ MGTFIGVYLP
CVQSILGVIL FLRLTWIVGT AGIMGSFAMV FMCCACTLLT AISMSAIATN GMVPAGGSYY
MISRALGPEF GGAVGLCFYL GTTFAGSLYI LGTIEIFLMY IMPNAEVFET REHNMRLYGT
CCLASMVLVV FVGVKYVNKL ALVFLSCVIL SIMAIYAGVI RTAIQPPDVQ ICMLGDRLLG
NQNFKCVKTE VIDNITYPTK LRELFCDGPF LNATCDEYFI QNNVTEMKGI PGLLSGVISR
ENNLWGNYGP FGSLVEMRQQ SEALQDYSNV NRPYVLNDIT TYFTLMVGIF FPSVTGIMAG
SNRSGDLRDP QRSIPTGTIL AIITTSITYM SFVVLFGACI EGVLLRDKFG YSVNRIPVLG
ILAWPSPWII VIGSFFSCCG AGLQSLTGAP RLLQAIAHDG IVPFLQVFGH SKFNGEPTWA
LLLTAVICEI GVLIASIDAV APILSMFFLM CYLFVNLACA IQTLLGTPNW RPRFKFYHWS
LSFLGMSLCL ALMFVSSWYH ALIAVVIAGC IYKYIEYRGA EKEWGDGIRG LSLNAARYAL
LKLEESWGIF KQWPQLLVLL SLDSDLAVKH PRLLSFTSQL KAGKGLTIIC SVLQGTYMLR
GTEAKRSMKT SMAVEKTKGF CHVVVCSNLR DGFSNLIQSA GLGGMKHNTV LIAWPNNWRQ
AEDTLTWKNF IETVRETTAA HQALLVAKNI DHFPSNAERL AEGTIDVWWI VHDGGLLMLL
PFLLRQHKVW KKCKMRIFTV AHLDDNSIQM KNDLQVFLYQ LRLDAEVEVV EMHERDISAF
TYEKTLVMEQ RCLLLKQMQL SRTEREREVI NGHVFHQRGT KTPARHRERN SPASDQVHMT
WTKDKLATER NRLREASAGV KDLFSMKPNQ SNVRRMHTAV KLNEAVVNKS QGAHLVLLNM
PGPPKNKDGD ENYMEFLEVL MEGLDQVLLV RGGGREVITI YS
//
