ID A0A4W4HR83_ELEEL Unreviewed; 950 AA.
AC A0A4W4HR83;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
OS Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC Gymnotoidei; Gymnotidae; Electrophorus.
OX NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000051984.1, ECO:0000313|Proteomes:UP000314983};
RN [1] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24970089;
RA Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H.,
RA Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R.,
RA Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.;
RT "Nonhuman genetics. Genomic basis for the convergent evolution of electric
RT organs.";
RL Science 344:1522-1525(2014).
RN [2] {ECO:0000313|Proteomes:UP000314983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28695212;
RA Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.;
RT "A tail of two voltages: Proteomic comparison of the three electric organs
RT of the electric eel.";
RL Sci. Adv. 3:e1700523-e1700523(2017).
RN [3] {ECO:0000313|Ensembl:ENSEEEP00000051984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A4W4HR83; -.
DR STRING; 8005.ENSEEEP00000051984; -.
DR Ensembl; ENSEEET00000052547.1; ENSEEEP00000051984.1; ENSEEEG00000024395.1.
DR GeneTree; ENSGT01030000234563; -.
DR OMA; RRNDGNC; -.
DR Proteomes; UP000314983; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 2.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314983};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 861..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..639
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 950 AA; 107257 MW; 00BFB34E5A2CA2E5 CRC64;
IMVLTDPEFE SSVLISSDEG ASYQKYRLGF YVLSLLFHPE KEDWILAYSH DQKLYSSFDF
GRKWQLVHER VTPNRFYWCV SGLDKEADLV HIEAHTPDGH CQYMTCRAQA CLESARTFPF
PGYIEPNSLV VQDNYIVVQV TMAGRAAYYV SYQREPFVLI KIPKYSLPKD MHILSTDQGQ
VFAAVQEWNQ NDTYNLYISD QRGVFFTLAL ENVKTSRGLG GNSMIDLYEV AGIKGMLIAN
RKVENQVKTY ITYNKGRDWR MLQAPSKDLE GNDIHCVLPF CSLHLQLQMS ENPYLSGSIT
TKSSVPGVIV ATGNIGSELS YNNVGMFVSS DAGNTWRHIF EEEHNVWFLD EGGALLAVAQ
PAAPVRHLWY VFDEGRQWTR HSFSAMPLYV DGVLVEPGSE SQVLTFFGHF SDRSEWQLIK
IDYKSLFTKQ CTEGDYQTWH LHNQGEPCVM GQKQIYMKRR PGNYCMLGRE SSRILSAEPC
ICRAHDFECD YGYERRGAGT CLAAFWFNPA TVSASCSHGQ NYLNSTGYRK VVANNCTKGV
KEMYLPRKQV CPERPPRGLQ LGTREGKLTA NLGSNVTFVV QLEEGDSLRT NIQLDFGDGT
AVSYSNLSWT EDGIKHVYRS AGIFRVSALA ENSLGYDSTS LYLHVTCPVE HVQLLAPFVV
IKNKEVNLTA VVWPSHCRTL TYFWWLGNST EPVITLEGSI PHVFSAEGMN TVTVQVSSAN
SILQDTKTIA VQEFFKSLLL SFSPNLDEAN PDIPEWRQDV GRVIKKALLQ IADVPTEQLL
VAVFPGIPTA AELFLLPSKN QSEGRKRSEE DLEQISEVLI IALNQNLVEF ELKPGSRVIV
YITQLTLAPL VDSIPRHSSS AMLMLLSVVF LGLAVFLIYK FKRKIPWINI YAEVNHEKEQ
EMLGTVGQSD AAPKITLSEF STPKEMMEKE LDARLKREQS SFTPPTLFDH
//
