ID A0A4W5KJW0_9TELE Unreviewed; 2798 AA.
AC A0A4W5KJW0;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Neurofibromin 1b {ECO:0000313|Ensembl:ENSHHUP00000010690.1};
GN Name=NF1 {ECO:0000313|Ensembl:ENSHHUP00000010690.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000010690.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000010690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 62062.ENSHHUP00000010690; -.
DR Ensembl; ENSHHUT00000011029.1; ENSHHUP00000010690.1; ENSHHUG00000006415.1.
DR GeneTree; ENSGT00550000074797; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982}.
FT DOMAIN 1197..1413
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1542..1700
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2743..2798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2761..2788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2798 AA; 315521 MW; A90342BC5F9F0869 CRC64;
MAAHKPVEWV QAVISRFDEQ LPVKVGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTN
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD CMRLDETMLV KQLLPEICHF
IHTYREGHQH ATELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED TVDVHDIELI
QYINVDCAKL KKLIQETVFK FKALKKPAQL SVINSLEKAF WNCVENYPDE FTLLYQRPQT
DMADCAEKLF DLVDSFAESA KRKAAVWPLQ IILLILCPDI TQDLSRETVE DTKVNKKLFL
ENLRKALAGH GGSKQLTESA AIACVKLCKA STYINWEDHS VIFLLVQSIV VDLKALLFNP
AKPFSRGAGS QNADVDLMID CFVSCFRINP HNNQHFKVCL ASSSPPTFHF VLVNSLHRII
TNSPLDWWPK IAAVYCYSGE LRVMFSETLG HVMRGCSTHA PLRMTPSLTF KEKMTSLKFK
EKTTDLDTRS LLLALVKLIH ADPKLMLHNP GKQGQEIQSS TAELITGLVQ LVPLANMGEC
SQEAMEALLV LHQPETIELW NPDAPIETFW DISSQVLFFI CKKLVGHQMI NSTEILKWLR
EILICRNKFL LRNKVGYCVV SYVFLIPVCL IQEGTTLYNV YMGSGIPICR QAQTKLEVSL
YMFLWSPDME AVLVAMSCFR HLCEEAEVRC CVDEVPVQTI LPNYNTFIEF ASVSNMMSTG
RSALQKRVMA LLRRIEHPTA GNKEAWEDTH AKWEQATKLI LTHPKTKLED GQASTHPVPC
CYAFSLRKSK IHFTYYLVEW VNMTGFLCAL GGVCLQQRSA PGLATYSPPM GPLSERKGSM
ISMGSCEGNT ETPLGRFLDR LLSLMVCSHE KGVQIRTNVK DLVGLELSPA LYPMLFNKLK
NSISRFFDAQ GPVPINDTNT QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY
VRILGNMVHA IQIKTKLCQL VEVMMERRDD LSFCQEMKFR NKMVEYLTDW VMGTSNQAAD
DDVKCLTRDL DQASMEAVVS LLAGLPLQPE EGDGVELMEA KSQLFLKYFT LFMNLLNDCS
EVEDDGQQVA GRKRGMSRRL ASLRHCTVLA MSNLLNANVD SGLMHSIGLG YHKDLQTRAT
FMEVLTKILQ QGTEFDTLAE TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE
LARVLVTLFD SRHLLYQLLW NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ
KLLEPLLRGV ITAPEWQLIS FEVDPTRLDQ SEILEENQRN LLQITNRFFL AIINSSTEFP
PQLRSVCHCL FQATCHSLLN KATVKEKKES KKAVVSQRFP QNSIGAVGSA MFLRFINPAI
VSPYEAGILD KKPPPRIERG LKLMSKILQS IANHVLFTKE EHMRPFNDFV KSNFDAARRF
FLDIASDCPA SDSVNHSLSF ISDGNVLALH RLLWNNQEKI GQYLSSNRDH KAVGRRPFDK
MATLLAYLGP PEHKPVADTH WSSLNLTSSK FEEFMTRHQV HEKEEFKALK TLNIFYQAGT
SKNGNPVFYY ITRRFKTGQI NGDLLIYHVL LTLKPYYAKP YEIVVDLTHA GPSNRFKTDF
LSKWFVVFPG FAYENVVAIY IYNCNTWVRE YTKYHERLLT GLKGSKKLLF IDSPARLAEH
VEPDQQKLPA ATLALEEDLK VFHNALKLAH KDTKVSIKVG STAVQVTSAE RTRVLGQSVF
LNDIYYASEI EEICLVDENQ FTLTIANQGT PLTFMHQECE AIVQSIIHIR TRWELSQPDS
IPQHTKIRPK DVPGTLLNIA LLNLGSSDPS LRSAAYNLLC ALTCTFNLKI EGQLLETSGL
CIPANNTLFI VSISKTLAAN EPHLTLEFLE ECISGFSKSS IELKHLCLEY MTPWLLNLVR
FCKHNDDAKR QRLTAILDKL ITMTINEKQM YPSIQAKIWG SLGQITDLLD VVLDSFIKTS
ATGGLGSIKA EVMADTAVAL ASGNVKLVSS KVIIRMCKII DKTCLSPTPT LEQHLMWDDI
AILARYMLML SFNNSLDVAT HLPYLFHVVT LLVATGPLSL RASTHGLVIN IIHSLCTCSQ
LNFSEETKQV LRLSLTEFSL PKFYLLFGIS KVKSAAVIAF RSSYRDRSFS PGSYERETFA
LSSLETVTEA LLEIMEACMR DIPGCKWLDQ WTELAQRFAF QYNPSLQPRA LVVFGCISKR
VTHGQIKQII RILSKGLESC LKGPDNYNSQ VLIEATVIAL TKLQPLLNKD SPMHKALFWV
AVAVLQLDEV NLYSAGTALL EQNLHTLDSL RVFNDKSPEE VFMEIRKPLE WHCKQMDHFV
GLNFNSNFNF ALVGHLLKGY RHPSPNTVAR TIRILHTLLA LVGKHLNCDK FEVNTQSVAY
LAALLTVSEE VRSRCSLKHR KSLLLSEVTM ENVPMDTYSV HHSDPCCRTL QESQPWTSPK
VSERYLVAHY SSVGQISPRT RKSMSLDMGQ PSQANTKKLL GTRKSFDHLI SDNKAPKRPD
MESGITTPPK MRRVAENDYE IESTQRISHH TLRKVSVSES NVLLDEEVLT DPKIQALLLT
VLATLVKNTT DDFDQRILYE FLAEASVVFP RVFPVVHNLL DSKINTLLSL CQDPNLLNPI
HGIVQSVVYH EESPPQYQPS YLQSFGFNGL WRFAGPFSKQ TQIPDYAELI VKFLDALIDT
YLPGIDEETS EECLRTPTSP YPPPVQSQLS ITANLNLSNS MTSLATSQHS PGIDKENVEL
SPTTGHCNSG RTRHGSASQV QKQRSAGSFK RPSIKKIV
//
