ID A0A4W5LNN9_9TELE Unreviewed; 842 AA.
AC A0A4W5LNN9;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 2 {ECO:0000313|Ensembl:ENSHHUP00000027513.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000027513.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000027513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A4W5LNN9; -.
DR Ensembl; ENSHHUT00000028607.1; ENSHHUP00000027513.1; ENSHHUG00000017317.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 76..112
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 312..350
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 654..766
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 316..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 842 AA; 94628 MW; B8A47DBFACD38FCC CRC64;
CDGCPIDAIC QNTQASYKCT CKVGFKGDGK HCEDIDECDI EYNGGCVHEC NNIPGNYRCT
CHDGFNLAHD GHNCLDVDEC VFNNGGCQYT CVNTMGSYEC RCKEGFFLSD NQHTCIHRSV
EGLSCMNKEH GCAHICKETP KGGVACECRP GFELAKNQRG CILTCIHGNG GCQHTCEDME
QGPICRCHVR YTLHPDSRSC VERDETTTES SDHNATSFIE VDKRVKRRLL MENCAVNNGG
CDSTCKDTST GVRCSCPVGF TLQPDGKTCK DINECELHNG GCDHFCRNTI GSFECNCWKG
FKLLTDEHTC QDIDECYFER TCGHTCVNSP GGFECVCNKG YTLYGLAHCG DINECSVNNG
GCEQGCENTM GGFECHCHPG YKLHWNKKDC IGKTPPSKPT LNCSRQEGGD RCYLTCQSQV
HITSGELSVT TTTTIGLKWW IKCPGVCVLE WICTQVCVSV YFSTGMCVWF CLRVYCGLIA
LRGQFWYLVF LSTESCDLGC VRRRSEKRLR KTIRTLKKSI HREQFHLHFA GSNYELAKRL
ARPVDLPEHC GKGQVLVDRK CGQCPPGQFS HDSFIPCLPC PLGTYQPEVG RTSCFHCGGN
LVTKHNGAVS FQECETKVVC AYVCVCMCMY LCVSLLCSNK YCSCPALGCY YRHCGGELGD
FTGYIESPNY PGNYPANIEC TWTINPPPKR RILIVVPEIF LPIEDECGDY LVMRKSSLSN
SVTTYETCQT YERPIAFTSR SKRLWIQFKS NEGNSGKGFQ VPYVTYDEDY QELIEDIVRD
GRLYASENHQ EILKDKKLMK ALFDVLAHPQ NFFNYTAQES REMFPKSFIR FLRSKVLRFL
RP
//
