ID A0A4W5MCL7_9TELE Unreviewed; 624 AA.
AC A0A4W5MCL7;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Premelanosome protein b {ECO:0000313|Ensembl:ENSHHUP00000036531.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000036531.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000036531.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR AlphaFoldDB; A0A4W5MCL7; -.
DR STRING; 62062.ENSHHUP00000036531; -.
DR Ensembl; ENSHHUT00000037990.1; ENSHHUP00000036531.1; ENSHHUG00000022933.1.
DR GeneTree; ENSGT00950000183188; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR PANTHER; PTHR11861:SF12; SILVER HOMOLOG (MOUSE) B; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..624
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021289311"
FT TRANSMEM 545..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..282
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 331..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 67018 MW; A5E3152F6CAB90F5 CRC64;
MKTGTVLAVL LLALFSSAAA KPKSRFTRYP SWNTKMYPVW KDEDPRYKDS WKGGKVKFIV
GNDAPTLTAA KVTFTIELQF PHNQKVMPDG EVVWAENLTV NGTHYHQSEP VYPAQNTEWN
GVFPDGTPFR KGGDKPPPYV FVWKTWGQYW QVSDGPSSSL TIGTDNVPLG SYIVDIVIYH
YRSHEKFIPL GYASTQFSIT DQIPFAVSMS QVNDVNEADL SFVQNRAIAF TISLHDPSEY
LRDADITYNW DFGDSSGALI SRELTVTHTY IVAGGFKPQV VVQAVIPDKA CATPAGVIPT
GSTVTIGPAN LAGTTVRDPA AATSAGPVMA ATQGGTINGG PSVPAETDTE EDMTEVGASP
AQHTKTPSPV NPDTSTVSAG LTTASSEVEP AGETATPQAP VVIVVKREAV EKPKDDDCVI
YRYGSFCAGI DIVEGIESLK IVQVDNALIK TDEFEVERNV VDLTVTCHGS LPTEVCMVVS
DADCLMPVHT MCNTVSPSSE CQLVLRHFFN DSGIFCINVS MTNDVSLAVT SAKVSVTIGS
GLSSVGTVAM VMGLLIVALV TGSVAYTYKL FKAYRPLKEE SVVGSSSQSA DSSPGWSSGP
LLFWNLLSRQ APVENSPLLD DRLV
//
