ID   A0A4W5MEV0_9TELE        Unreviewed;       939 AA.
AC   A0A4W5MEV0;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Solute carrier family 12 member 7b {ECO:0000313|Ensembl:ENSHHUP00000035905.1};
OS   Hucho hucho (huchen).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Hucho.
OX   NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000035905.1, ECO:0000313|Proteomes:UP000314982};
RN   [1] {ECO:0000313|Proteomes:UP000314982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Macqueen D.J., Gundappa M.K.;
RT   "Genome assembly of Danube salmon.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSHHUP00000035905.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A4W5MEV0; -.
DR   Ensembl; ENSHHUT00000037340.1; ENSHHUP00000035905.1; ENSHHUG00000022583.1.
DR   GeneTree; ENSGT00940000157657; -.
DR   Proteomes; UP000314982; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 2.
DR   Pfam; PF03522; SLC12; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        138..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        217..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        498..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          144..242
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          389..580
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          594..711
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          720..930
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          10..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          839..858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   939 AA;  104109 MW;  D4E82C1C7884EE25 CRC64;
     MSERFVVVRV GQGDDGVKND PVADSGGADS GGAEGDSIDP PDSVPILEYS REPNRYGDGM
     PKESSPFINN TDHDKGNLYD GKNMALFEEE MDSNPMVSSL LNKLANYTNL TQGVKEHEEA
     DDDEGPARSK KPVKSPALGT LIGVYLPCLQ NILGVILFLR LTWIVGTAGI MESLAIVVMT
     CSCTMLTAIS MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGSMYILGT
     IEILLVSILC KDTVIFSTTS LNALSPSVLL TPYPNGNQDY NHSFLFVNKH QVSEPAADTS
     QDIYMPYVAN DITTFFTLLV GIYFPSVTGM FTWTSTCINR MKGKHSIYEW CTYILLINVT
     FLVNTSVCPR FGDSVKGNLV IGILAWPSPW VIVIGSFFSC CGAGLQSLTG APRLLQAIAR
     DGIVPFLQVF GHGKANGEPT WALLLTGGIC EIGILIASLD AVAPILSMFF LMCYLFVNLA
     CALQTLLCTP NWRPRFKFYH WALSFLGASL CLSLMFISSW YYALVAMLIA GCIYKYIEYR
     GAEKEWGDGI RGLSLNAARY ALIRLEEAPP HTKNWRPQML VLLNLESDHT VKHPRLLSFC
     TQLKAGKGLT IVGSVLQGTY MTKEVEVKEA EQNIKSSMTT ERTKGFCHVV ASSNLRDGFS
     HLIQTAGLGG MKHNTVLMAW PGTWKQSNDP VSWKNFIETV RETTAANQAL LVAKNVDSFP
     TNADRLGEGT IDVWWIVHDG GLLMLLPFLL RQHKVWRKCK MRIFTVANMD DNSIQMKKDL
     QMFLYHLRLD AEVEVVEMHD SDISAFTYEK TLVMEQRSQM LKQLQLSRTE REREAQLIHD
     RNTASHATLN DKPDTGPDRV HMTWTKDKLL SERNRNRSEA NMGVRDLFNM KPNQSNVRRM
     HTAVKLNEVV VNRSQGTHLV LLNMPGPPKN RGGDENCIL
//