ID A0A4W5MLH8_9TELE Unreviewed; 874 AA.
AC A0A4W5MLH8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 1 {ECO:0000313|Ensembl:ENSHHUP00000038549.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000038549.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000038549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A4W5MLH8; -.
DR Ensembl; ENSHHUT00000040068.1; ENSHHUP00000038549.1; ENSHHUG00000023917.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 211..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 250..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 684..796
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 381..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 215..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 874 AA; 96954 MW; 5A503D15FCEC2DA5 CRC64;
CDCKMTDVYD FTELTVLSFV RAGLTVTPLC YPQRGWNGRQ ECLTHLFYGM NCMNKDHGCA
HICRETPKGG VACECRPGFE LAKNQRDCSL TCNYGNGGCQ HMCDDTDVGP VCGCHQKYAL
HSDSKTCIET CAVNNGGCDR TCKDTATGVR CSCPVGFTLQ PDGKTCKDID ECQEAFNNGG
CDHFCKNTVG SFECSCQKGH KLLTDERTCQ DIDECSFERT CDHTCVNYPG SFDCVCQEGY
TLYGLTHCGD IDECSINNGS CEHSCVNTQG GYECLCPPGQ KLHWNKKDCT KAVKCLPNGK
PAPRAQLSCD KRGGVEVCSL SCPSNALFLA DSENSYTLSC GVPVQPGKAP QKRNATAALL
TYTLPPPIKQ KARFKIKDAK CHLRPRNKEK HRETSKPSLQ GGPLPCTDDC QVTFVNLKCD
SSKKRRRGRK SPSKEVSHIT AEFEMEMKEA SDSCNVECVR ERMKQRLQSA MRTLRKSINK
QQFYIQFSGT EYDVAQKPAL HVEQCSTGQV LRDGKCVSCG VGTYYSGDHD QCVVCPPGTY
QDTMGQLSCE PCPSTEGQGI AGAQNVSQCG GQCPAGQYSS DGFRPCNPCP LGSFQPEPGR
VLCFSCGGGL MTKYEASVAF RDCEAKVHCA PGHHYNSSNH RCIRCPASTY QSEFGQNYCI
TCPGNTTTDF DGATNVSHCK NQVCGGELGD FTGFIESPNY PGDYPSNVDC IWTINPPHKR
RILIVVPEIF LPIEDECGDV LVMRKSALPT SITTYETCQT YERPIAFTSR SRKLWIQFKS
NEGNSGKGFQ VPYVTYDEDY QQLIEDIVRD GRLYASENHQ EILKDKKLIK ALFDVLAHPQ
NYFRYTAQES KDMFPRSFIK LLRSKVTRFL RPYK
//
