ID A0A4W5NGK4_9TELE Unreviewed; 857 AA.
AC A0A4W5NGK4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 3 {ECO:0000313|Ensembl:ENSHHUP00000048414.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000048414.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000048414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A4W5NGK4; -.
DR Ensembl; ENSHHUT00000050171.1; ENSHHUP00000048414.1; ENSHHUG00000029074.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..56
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 99..135
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 183..223
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 224..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 667..779
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 228..238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 857 AA; 95763 MW; BB407F3A11359AE3 CRC64;
MIKYLTVPSI SPSLSDVDEC AEQIDNCSTD AICQNTLKSY KCICKSGYKG DGKHCEDLDE
CASEYNGGCV HDCINIPGNY RCTCYDGFRL AHDGHNCLDV DECSEGNGGC QQICVNMMGS
YECRCREGFF LSDNQHTCIQ RPKETCLVNN GGCDSTCHDA VTGVRCSCPV GFTLQPDRKT
CKDIDECRLN NGGCDHVCRN TVGSFECSCK KGYKLLTNER TCQDIDECSF DRACDHSCVN
SPGSFQCFCH KGYVLYGLAH CGDIDECSIN RGSCKYGCVN TQGSYECTCP TGYKLHWNRK
DCTVSMGLYI VPICATAYLQ LLWTEWFYCS VVHLYTHPPT LLCLPVETGA PPVKQTASFK
IKDAKCHLHP KLTGRAEDRG RPCNNCLVTF VNLKCDSSKK AKGRRVRNPT NKEVTRITLE
LEAEVKPGDT TGSCNLSCLR QRMEKQVKTY IKALKKSINQ ERFLIRVAGL EYEVAQKLPQ
VASGHENCGP GREKDSGRCV KCLPGSYYHG EQERCIQCPP GTFQEREGQL ACDLCPGSDG
HGPAGARNIS SCAGQCPTGY FSSDGFQPCQ PCPFGSYQPD LGRTLCFPCG GGLSTKREGS
SSFHDCEVKV QCSPGHYYNT TVHRCIRCPL GSYQTEFRQN YCITCPGNTT TDFDGATSVS
QCKNRECGGE MGEFTGYIES PNYPGNYPAN VECIWIINPP NKRKILMVVP EIFLPSEDEC
GDVLVMRKNW SATSITTYET CQTYERPIAF TARSRRLWIN FKSNEANSAR GFQIPYVTYD
EDYEQLVEDI VRDGRLYASE NHQEILKDKK LIKTLFDVLA HPNNYFKYTP REFSEMLPRS
FLRLISSKVS AFLRPYK
//
