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Database: UniProt
Entry: A0A4W5NHB7_9TELE
LinkDB: A0A4W5NHB7_9TELE
Original site: A0A4W5NHB7_9TELE 
ID   A0A4W5NHB7_9TELE        Unreviewed;       474 AA.
AC   A0A4W5NHB7;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Cathepsin F {ECO:0000313|Ensembl:ENSHHUP00000049348.1};
OS   Hucho hucho (huchen).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Hucho.
OX   NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000049348.1, ECO:0000313|Proteomes:UP000314982};
RN   [1] {ECO:0000313|Proteomes:UP000314982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Macqueen D.J., Gundappa M.K.;
RT   "Genome assembly of Danube salmon.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSHHUP00000049348.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   AlphaFoldDB; A0A4W5NHB7; -.
DR   STRING; 62062.ENSHHUP00000049348; -.
DR   Ensembl; ENSHHUT00000051131.1; ENSHHUP00000049348.1; ENSHHUG00000029867.1.
DR   GeneTree; ENSGT00940000164681; -.
DR   Proteomes; UP000314982; Unassembled WGS sequence.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   Gene3D; 1.10.287.2250; -; 1.
DR   Gene3D; 3.10.450.10; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411:SF947; CATHEPSIN F; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00043; CY; 1.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54403; Cystatin/monellin; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..474
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5021361932"
FT   DOMAIN          31..140
FT                   /note="Cystatin"
FT                   /evidence="ECO:0000259|SMART:SM00043"
FT   DOMAIN          176..233
FT                   /note="Cathepsin propeptide inhibitor"
FT                   /evidence="ECO:0000259|SMART:SM00848"
FT   DOMAIN          261..472
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   474 AA;  53014 MW;  A755676F6833491E CRC64;
     MDVGFRHPIL LCLTLAVLGS VLADLDGPLM GAPGSAVRLS ENDPGLKKAL KFAEQRYNEG
     SNAMHVRRVS KILSASKQLV KGIRYSIMVE LSNTQCKKAA RLRICDFCPE EHNLKTEVCV
     FEVWDIPWES KSSLLKQKCQ PAVDPKPVET NKVEFLPLST KPVEESVDSV ELLGQFKEFM
     VRYNRTYSSQ EEADRRLRVF HENLKTAEKL QSLDQGTAEY GVTKFSDLTE EEFRTLYLNP
     LLSQQNLQQS MKPAAMPRGP APPSWDWREH GAVSPVKNQG MCGSCWAFSV TGNIEGQWFA
     KTGKLVSLSE QELVDCDTVD QACGGGLPSN AYEVIEKLGG LETETDYSYT GKKQSCDFTT
     DKVTAYINSS VELSKDENEI AAWLAENGPV SVALNAFAMQ FYRKGVSHPL KIFCNPWMID
     HAVLLVGYGE RQGKPFWAIK NSWGEDYGEH GYYYLYRGSR LCGINKMCSS AIVN
//
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