ID A0A4W5NIL8_9TELE Unreviewed; 896 AA.
AC A0A4W5NIL8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Sortilin-related VPS10 domain containing receptor 2 {ECO:0000313|Ensembl:ENSHHUP00000049145.1};
GN Name=SORCS2 {ECO:0000313|Ensembl:ENSHHUP00000049145.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000049145.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000049145.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A4W5NIL8; -.
DR Ensembl; ENSHHUT00000050924.1; ENSHHUP00000049145.1; ENSHHUG00000029741.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR Pfam; PF18911; PKD_4; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 597..667
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 896 AA; 100904 MW; 50681050E62D3059 CRC64;
MLMQRFCKTC NSLRPTILTS LFLSLFLLRS SDYGTTYSKL NLMPGTTIVV SNFYICPTNK
KKVGSLQPAL SIFSPPLTCN DMIAAISYWQ LPLSPLTLKT VIVEGQHTAA LGKLGYMVLD
GYLYVTCLIQ NCSDKMVTAQ FLGKIDHNSL SVQDDYIFVK VTTGNRTKHY VSYRRNEFVQ
MRFPKYALPK DVHIVSTDEN QVFLALQEWY QTDTYNLYQS DPQGVYYSMV LENVRSTKQP
EESVLIDILE VRGVKGVFMA NQKVDGKVTT LITYNKGRDW EPLAPPTTDM NGKPVTCRSV
RNPCITSIPI RIKCLAQNRQ IFYHVGSEIQ SSDLSVPGPA LLTARLPVFE EEHHILYLDH
GGVIVAIKDT SIPLKILKFS IDEGRTWSIH NFTSTSVFVD GLLSEPGDET LVMTVFGHIS
YRSDWELVKV DFRQSFPRQC TEADYDSWKL TDLKGEKCIM GQERSFRKRK DTAFCIKGKS
YTSALTTKTC QCSEKDFNCD YGFERAQSLK AEGDRCFADF WHDPDSPPDD CHLGHDFESS
TGYRKVVSNM CEGGVNKQQS AKQHTCPLLP PRGLQLGIKG QMLAVAPGDD ITFIVHQEQG
DTSNTKYQVD LGDGVRAIYQ NLTVTDEPIQ HRYEQLGVYR VTVKAENMAG HDQATMYIQV
TAPLQEVHLE VVPIAGVNQE VNLTAVVLPS EANLTVFYWW IGDNLQPKLS LENSLITRFP
EEGEVSVTVQ ASNGRSMVQD TKAVHLFQVI PLAFSSNLDL LNPNIPEWRE DVGQVVTRIL
AKITGIPQES LVTMVKPGLP TTADLYILPP ESNPWLRTED AYPPLFFRKL PGRNVYAQMH
NEKEQEMTSP VNHSEDTQHI IQGEEFIDDD LDSQTLGNAG GSPAFRSLIR TNPHYY
//
