ID A0A4W5P8H4_9TELE Unreviewed; 825 AA.
AC A0A4W5P8H4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000057850.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000057850.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A4W5P8H4; -.
DR Ensembl; ENSHHUT00000059837.1; ENSHHUP00000057850.1; ENSHHUG00000034301.1.
DR GeneTree; ENSGT00940000158442; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF24; BAND 4.1-LIKE PROTEIN 1; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PIRSF; PIRSF002304; Membrane_skeletal_4_1; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982}.
FT DOMAIN 47..329
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 23..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..446
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 93752 MW; 5308A3ADB7D30C52 CRC64;
MNFTCDYECP YVKDQDSKLI DDHREIDDVS EKTPKSPQKT SKRPKTVPFK VTLLDTSDYE
AGIEKHCKGQ ALLDMVCEHL NLLEKDYFGL TYSDAESQKS TWAVNSSHLL CCSSAAPWHF
AFSVKFYPPD PSQLTEDITR YYLCLQLRDD MLSGRLPCSF VTHALLGSYA VQAELGDYDT
DDHGPDYVSD FRFAPNQTRE LEERVMELHR NYRGMTPADA EINFLENAKK LSMYGVDLHH
AKDSEGIDIM LGVCANGLLI YRDRLRINRF AWPKILKISY KRSNFYIKIR PGEYEQFEST
IGFKLPNHRA AKRLWKVCIE HHTFFRLVSP EPPPKGFLVM GSKFRYSGRT QAQTRQASAL
IDRPAPHFER STSKRYLLSR SLDGVSAMCE IQDGLSQHSG SEHPHLHSPS GDEQETELEP
PSLEQDQEED QDEEQDLEEY HDQEEDEDGV PTPSKKKEIK FLDKSEDVLL KHQASINELK
RALREPNSKL MNREKRLSGT SPGGTPEKKA EPLPTPAIYE DTVEDAKREP WERRPRPGSA
SEEDHERDTV VSMKDTHLGI ERKCSSMTVS STSSLEAEVD FTVIMDLHTG VEEFSKSMSK
LGELGERLPE VGRDDFEETS RFYSARLMVS HDMSPVEEMP PGILIKLDQR HSIVLYLHSL
TVPVCLALLQ PPVARKDPSA VSAAQMLRKA DAKMETHTNG SEVTSTNIMD MSEQVHYNQA
MPMDSHLSPC LWWMIPPGTV VSSVCTVKGG YSETRIEKRI IITGDDDVDQ HQALAMAIQE
AKQQHPDMLV TKAVVVRETE SPTEEQHRTS EVRTELHVNI TVMTP
//
