ID A0A4W5PYR2_9TELE Unreviewed; 1845 AA.
AC A0A4W5PYR2;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Trio Rho guanine nucleotide exchange factor {ECO:0000313|Ensembl:ENSHHUP00000065394.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000065394.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000065394.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSHHUT00000067609.1; ENSHHUP00000065394.1; ENSHHUG00000038348.1.
DR GeneTree; ENSGT00940000154766; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11852; SH3_Kalirin_1; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR028570; Kalirin_TRIO_SH3_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF210; CRAL-TRIO DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16609; SH3-RhoG_link; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 6.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..151
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1229..1404
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1416..1528
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1592..1659
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1545..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1679..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 693..720
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1679..1701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1773..1792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1845 AA; 210892 MW; 025848D109AF04A5 CRC64;
MKAIDVLPIL KEKVAFISGG RDRRGGPVLT FPARSNHDRI RTEDLRRLIA YLAGIPSEEV
SRHGFTVIVD MRGSKWDSIK PLLKILQESF PSCIHVALII KPDNFWQKQR TNFGSSKFEF
ETVMVSLEGL TKVVDPSQLT SDFEGSLEYD HDEWIEVRVA FEDFAGDAAR ALARLEELQE
TLAQRDLPRD LEGARRLMEE HASLKKRATK ASVEELDTQG RRLLQRLQQG SVTPGGHPDA
HNLVPKVSAL LDKLHGTRQH LQQLWHMRKL KLDQCFQLRL FEQDAEKMFD WIMHNKGLFL
TSYTEIGGNH QHAGELQTQH NHFAMNCMNV YVNINRIMSV GNRLLESGHY ASQQIQQISG
QLEQEWKAFA AALDERSTLL EMSAAFHLKV DQYMSNVEPW CKACGEGDLP SELQDLEDTI
HHHTGLYEHI TTAYTEVSQD GKSLLDKLQR PLTPGSADSL MASANYSKAV HHVLDIIHEV
LHHQRQLENI WQHRKVRLHQ RLQLCVFQQD VQQVLDWIEN HGEAFLSKHT GVGKSLHRAR
ALQKRHEDFE EVAQNTYTNA DKLLEAAEQL AQTGECDPEE IYQAAHQLED RIQDFVRRVE
QRKVLLDMSV AFHTHVKELW TWLEELQKEL LDDVYAESVE AVQDLIKRFG QQQQTTLQAT
VNVIKEGEDL IQQLRDSAIS SNKTPHNSSM AHIQSVLQQL DEAQAQMEEL FQERKIKLEL
FLQLRIFERD AIDIISDLES WNEELSQQMG EFDTEDLTLA EQRLQHHADK ALTMNNLTFD
VIHQGQELLQ YVTEVQASGV ELLCDRDVDM ATRVQDLLEF LHEKQQELDV AAEQHRRHLE
QCVQLRHLQA EVKQVLGWIR NGESMLNAGL ITASSLQEAE QLQKEHEQFQ HAIEKTHQSA
LQVQQKAEAL LQANHYDMDM IRDCAEKVAD HWQQLMLKME DRLKLVNASV AFYKTSEQVC
SVLESLEQEY KREEDWCGGA DKLGPNSESD HVTPMISKHL EQKEAFLKAC TLARRNADVF
LKYLHRNSVN MPGMLSHVKA PETQVKNILN ELLQRENRVL HFWTMRKRRL DQCQQYVVFE
RSAKQALEWI HDTGEFYLST HTSTGSSIHH TQELLKEHED FQITAKQTKE RVKLLIQLAD
GFCDKGHAHA LEIKKWVTSV DKRYRDFSLR MDKYRSCLEK ALGIISSDSN KASKGLQLDI
IPASVPGSEV KLRDAAHELN EEKRKSARRK EFIMAELIQT EKAYVRDLRE CTDTYLWEMT
SGVEEIPPGI VNKEHIIFGN MLDLYEFHHN IFLKELEKYE QLPEDVGHCF VTWADKFQMY
VNYCKNKPDS TQLILEHAGP YFDEIQQRHR LANSISSYLI KPVQRITKYQ LLLKELLTCC
EEGKGEIKDG LEVMLSVPKR ANDAMHLSMM DGFDGNIDSQ GELILQESFQ VWDPKTLIRK
GRERHLFLFE MSLVFSKEVK DSNGRNKYLY KSKLFTSELG VTEHVEGDPC KFALWVGRTP
SSDNKMVLKA SSVENKQDWI KHIREVIQER TIHLRGALKE PIHIPKATTV KHKGRSHGDD
LDSQGDACSQ PDTISIASRT SQNTLDSDKL SGGCELTVVI HDFVASNGSS SELTVRRGQT
VEVLERLHDK PDWCLVRTTD RSPAQEGIVP CAMLCIAHSR SSMEMEGLFN HHHKDTLSVS
SNDAIQPGAS HTLSFHSSPG PKRPGNTLRK WLTSPVRRLS SGKADGHVKK LAHKHKKNRD
GRSKNADSAG SQKDSDDNAA TPQDETIEER MRNEGLSSGT LSKSSSSGMQ SCGEEEGEEG
ADAVPLPPPM AIQQHSLLQA DSQDDKLYVD FCSASVLSQF PYLSM
//