ID   A0A4W5QMH0_9TELE        Unreviewed;       890 AA.
AC   A0A4W5QMH0;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=MCF.2 cell line derived transforming sequence a {ECO:0000313|Ensembl:ENSHHUP00000077312.1};
OS   Hucho hucho (huchen).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Hucho.
OX   NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000077312.1, ECO:0000313|Proteomes:UP000314982};
RN   [1] {ECO:0000313|Proteomes:UP000314982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Macqueen D.J., Gundappa M.K.;
RT   "Genome assembly of Danube salmon.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSHHUP00000077312.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A4W5QMH0; -.
DR   STRING; 62062.ENSHHUP00000077312; -.
DR   Ensembl; ENSHHUT00000079823.1; ENSHHUP00000077312.1; ENSHHUG00000045138.1.
DR   GeneTree; ENSGT00940000156974; -.
DR   Proteomes; UP000314982; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00170; SEC14; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314982}.
FT   DOMAIN          27..156
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          541..722
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          740..856
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          490..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          279..330
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   890 AA;  101970 MW;  D49E6856C9DACF14 CRC64;
     MSMKEVDGYI EKQVAYLSGG RGEDSSVIVT LPEYSAFSDI PEESLAKVLT YLTLIPRQPG
     VKFIIILDRR LDTWTSIKTA LARIAASFPG NLHLVLVLRP TSFFQRTVTD LGFRFSQEDF
     MLKMPVVMLS SVTDLLRYVD ENQLTSEFGG TLDYCHSDWI VLRTAIESYA VTVKDIAQML
     QAFGTELAET KLPDEGTAIV RLLSTHTDKY RTLKVYLSKE GRHLLASLEA SGREEDSLWD
     VRLDWETVQR LLAQLRGMES AFDGFFEKHH VKLQQYLQLL RYEHRFQEME LSLERLASQE
     REVSLSGETL TQTEQTLREL DSLEAHAQEE IGRAQIIILH GHQLAASHHY AMALIMQRCN
     ELRHRCDTLS NALRVKRTHL SQAHRLLLRL CQAQSWCDDG AYLLAQQLVG KFQSKEGAQA
     ALKDIDRFLE GTPSLLSSGH DLLAMEFESV LTPEIQVQHQ AMVQEMIHNR QVCLRKLADK
     HVRPIQLVAP RAESPPRSKS PLFSPKHGKR RQWSIHTHTH NHTHIQSHLM IQYISPLALC
     LHSHVMRELI ETERVYVEEL LSVLLGYRGE MENPALAGLL PPILRSKRNV LFGNMPEIYN
     FHSRVFLHDL EGCLETPEGV GACFLERKEN FQVYECYCQN KPRSESLWRQ FSHCAFFQEC
     QKKLEHKLGL DSYLLKPVQR LTKYQLLLKE LLKYSAGGCE GTSELQAALA AMLHLLKSVN
     DSMHQIAITG YQGELCDLGR VLMQGSFSVW ISHKKGPTRM KELTRFKPTQ RHLFLYERAL
     LFCKRREEHG EGADKTPSYS FKHCLKMSAV GITENVKGDV KKFEIWYSGR EEVYVVQAPT
     VEVKTAWLGE LRRILTNQQK LLKGLDVTHI TQQRTGFNSD QINSPSLHLT
//