ID   A0A4W5R836_9TELE        Unreviewed;       539 AA.
AC   A0A4W5R836;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE   AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
GN   Name=TYR {ECO:0000313|Ensembl:ENSHHUP00000082158.1};
OS   Hucho hucho (huchen).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Hucho.
OX   NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000082158.1, ECO:0000313|Proteomes:UP000314982};
RN   [1] {ECO:0000313|Proteomes:UP000314982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Macqueen D.J., Gundappa M.K.;
RT   "Genome assembly of Danube salmon.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSHHUP00000082158.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane
CC       {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004573}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC       {ECO:0000256|ARBA:ARBA00009928}.
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DR   AlphaFoldDB; A0A4W5R836; -.
DR   STRING; 62062.ENSHHUP00000082158; -.
DR   Ensembl; ENSHHUT00000084756.1; ENSHHUP00000082158.1; ENSHHUG00000047217.1.
DR   GeneTree; ENSGT00940000155336; -.
DR   Proteomes; UP000314982; Unassembled WGS sequence.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..539
FT                   /note="Tyrosinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5021258924"
FT   TRANSMEM        478..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          207..224
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          388..399
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   539 AA;  61529 MW;  C272AA02441054EF CRC64;
     VAMRLLLIHS VFFLQCVRFS QQQFPRLCAT TEALLSKECC PVWEGDGSAC GASSGRGFCR
     DVEVSDLPNG MNYPFSGLDD RERWPLVFYN RTCQCASNYM GFNCGECQFG LFGAKCEERR
     ESVRRNVFHL SAAERRKLIS YLNLAKHTFS QDYVIATGTY REMNNGSTPL FSDVSTYDVF
     VWMHYYVSRN ALLGGPGNVW TDVDFAHWAP AFLPWHRVYL LHWEREIRKL TGDFEFSIPY
     WDWRDAQGCD VCTDDLMGAQ SPRDPNLISP ASVFSSWRVM CSRAEDYSVR GVLCDGNYEG
     PLLRNPGNHN HNLVARLPTA AEVEFTVSLR DYDTGSMDRS ANFSFRNTLE GFGSPVTGLG
     NSREMGMHAS LHIFMNGSMS SVQGSANDPI FLLHHAYVDS IYEQWLRRHA PEQTHYPEFN
     APIGHNRQYH MVPFIPLHRN IEYFTSSKEL GYQYSYMLSS DQRISEVLSP YLELMMEAWP
     WLLGALVLGA LVTMTVAAVA ATMTRVCWGA WPWQRREKRS SFHLPEREPL IISSDSDTV
//