ID A0A4W5R9X6_9TELE Unreviewed; 1121 AA.
AC A0A4W5R9X6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSHHUP00000081139.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSHHUP00000081139.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000081139.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000081139.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A4W5R9X6; -.
DR STRING; 62062.ENSHHUP00000081139; -.
DR Ensembl; ENSHHUT00000083721.1; ENSHHUP00000081139.1; ENSHHUG00000046727.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF105; SOLUTE CARRIER FAMILY 12 MEMBER 2-LIKE; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..158
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 199..701
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 710..973
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 980..1121
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 122825 MW; B6DBC685B13AD04B CRC64;
MSSPSGQKPA LKTAGSGQSR FQVTEVTELG PVTSGERTSG GTDGTTGTTG SKGSAGGEES
KGRFSVVKFL DSGGIGTDAS DVAQNGDTVR STGSHRSSAS GHTNISDTHS NTYYMRTFGH
NTIDAVPNID FYRQTEAPLG DKLIRPTLSE LHDELDKEPL DEDGFPIGEE STLAEEAAAK
EGTKEQTKGG TIKFGWVKGV LVRCMLNIWG VMLFIRMSWI VGQAGIGLTC VIILMATVVT
TITGLSTSAI ATNGFVRGGG AYYLISRSLG PEFGGSIGLI FAFANAVAVA MYVVGFAETV
VEMLNDVDAL MTDELNDVRI VGTLTVILLL GISVAGMEWE AKAQIVLLVI LLAAIFNYFI
GTVITMESKE PKGFFGYKAA IMMENMGPDF RDGETFFSMF AIFFPAATGI LAGANISGDL
TDPQSAIPKG TLLAILITGI TYVAVTVSTG SCILRDATGD HNDTSSVSDL NCTDAACTLG
YDFSICKEGG CKFGLMNDFQ VMSLVSGFGP LITAGIFSAT LSSALASLVS APKVFQALCK
DNIYPGLHVF AKGYGKNNEP LRGYVLTFCI GLAFILIAEL NVIAPIISNF FLASYALINF
SVFHASLANS PGWRPSFKYF NKWVSLAGAV LCCAVMFVVN WWAALMTNII VLALYVYVSY
KKPDVNWGSS TQALIYNHAL THCLLLTGVE DHVKNFRPQC LVMTGYPNAR PALLHLVNAF
TKNVGLMVCG HVRTHLCTYI HSIHHTYSLQ LTHIFRSNSF DCFHCPKVSR RPNFKEMSLD
HARYQRWLLK NHIKAFYTPV FAEDLRHGAQ YLLQATGLGR LKPNTLVMGF KNNWSDGEMK
DVEMYINIIH DAFDLQHGVV IIRLQEGLDI SHIQDPDELL SSHEKKDAGM KDVVVSVNMV
GKDSEDSNSF PPSLITSAQN SPLILRETKR SAKPLSLTDQ RLLEASQQFK KKQCKGTVDV
WWLFDDGGTV WLISNRKITL MAALLSKFRI DFSAIYVLGD INTKPKKHNV LSFEEMIEPY
KLKEDDMEQE AAERLKAEEP WRISDNELEL YRAKTNRQIR LNELLKEHSN SAKLIVMSMP
LARKGTVSSA LYMCWLETLS KDLPPILLVR GNHQSVLTFY S
//
