ID A0A4W5RQX0_9TELE Unreviewed; 1041 AA.
AC A0A4W5RQX0;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 5a {ECO:0000313|Ensembl:ENSHHUP00000088348.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000088348.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000088348.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A4W5RQX0; -.
DR STRING; 62062.ENSHHUP00000088348; -.
DR Ensembl; ENSHHUT00000091097.1; ENSHHUP00000088348.1; ENSHHUG00000051041.1.
DR GeneTree; ENSGT00940000165387; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..198
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 314..597
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 611..728
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 742..867
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 973..1041
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 848..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 114271 MW; DDEF5D9917590126 CRC64;
SNREVIASYK SRKCAPQLGT LMGVYLPCIQ NIFGVILFLR MTWMVGIGGV IGSFIIVFMC
CSTTMLTAIS MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGICFYLGTT FAGAMYILGS
IELLLIYILP QAAIFKMEGL EGAEAEAAML NNMRVYGTIV LSFMATVVFV GVKYVNKLAL
LFLACVILSI LAVYAGVIKT AIEPPDFPVC LLGNRPLISK GFDVCAKTLE SGNGTVTTKL
WNVFCDSPFL NATCDEYFVN NNVSFIQGIP GVMSGILKEN LFGNYLEKGD LVAKKGIATV
EGPDDTLTNS NRYVLADITS FFTLLVGIYF PSVTGIMAGS NRSGDLRDAQ KSIPIGTIMA
ITTTSIVYMS AVVLFGACIE GVVLRDKFGE GVNGNLVIGT LAWPSPWVIV IGSFFSTCGA
GLQSLTGAPR LMQAISRDGV VPILRVFGHG KANGEPTWAL LLTAGICEIG ILIASLDAVA
PILSMFFLMC YMFVNLACAL QTLLRTPNWR PRFKFYHWAL SFLGMSLCLS LMFICSWFYA
IVAMVIAGSI YKYIEFRGAE KEWGDGIRGI SLSAARYALM RLEEGPPHTK NWRPQLLVLV
STDVEQNVEQ PRLLSLTNQL KAGKGLTIVG TALAGTYLEN HPQAQRAEQS LRKLMETEKV
KGFCQVTISS NMRDATSHLL QASGLGGLMH NTVLVSWPRN WKQADDIQTW RDFIELVRET
TAAHLALLVP KNITAFPSNG ERFSEGHIDV WWIVHDGGML MLLPFLLRQH KVWRKCRMRI
FTVAQMDDNS IQMKKDLTTF LYHLRIDAEV EVVEMHDSDI SAYTYEKTLV MEQRSQILKQ
INLTKTERER EIQSITDSSR GSIRRKNPAV VTTQLSVTEE QPGVSSKVEK PEEEVQLIHD
STTPTSPATP ATPLTPASEG GAQTPGSAQV QMTWTEKADG EPAKPPGVST PEGIKDIFNM
KPEWENLNQS NVRRMHTALR LNGVIVKKSS EAKLVLLNMP GPPNNRSGDE NYMEFLEVLT
EGLNRVLLVR GGGREVITIY S
//