ID A0A4W5S0G0_9TELE Unreviewed; 674 AA.
AC A0A4W5S0G0;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Signal recognition particle subunit SRP72 {ECO:0000256|ARBA:ARBA00018350, ECO:0000256|PIRNR:PIRNR038922};
GN Name=SRP72 {ECO:0000313|Ensembl:ENSHHUP00000091014.1};
OS Hucho hucho (huchen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Hucho.
OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000091014.1, ECO:0000313|Proteomes:UP000314982};
RN [1] {ECO:0000313|Proteomes:UP000314982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Macqueen D.J., Gundappa M.K.;
RT "Genome assembly of Danube salmon.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSHHUP00000091014.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER).
CC {ECO:0000256|PIRNR:PIRNR038922}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR038922}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}.
CC -!- SIMILARITY: Belongs to the SRP72 family.
CC {ECO:0000256|ARBA:ARBA00007676, ECO:0000256|PIRNR:PIRNR038922}.
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DR AlphaFoldDB; A0A4W5S0G0; -.
DR STRING; 62062.ENSHHUP00000091014; -.
DR Ensembl; ENSHHUT00000093822.1; ENSHHUP00000091014.1; ENSHHUG00000052516.1.
DR GeneTree; ENSGT00390000013264; -.
DR Proteomes; UP000314982; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-UniRule.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR013699; Signal_recog_part_SRP72_RNA-bd.
DR InterPro; IPR026270; SRP72.
DR InterPro; IPR031545; SRP72_TPR-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14094; SIGNAL RECOGNITION PARTICLE 72; 1.
DR PANTHER; PTHR14094:SF9; SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72; 1.
DR Pfam; PF08492; SRP72; 1.
DR Pfam; PF17004; SRP_TPR_like; 1.
DR Pfam; PF13174; TPR_6; 1.
DR PIRSF; PIRSF038922; SRP72; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038922};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|PIRNR:PIRNR038922};
KW Signal recognition particle {ECO:0000256|ARBA:ARBA00023135,
KW ECO:0000256|PIRNR:PIRNR038922};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 223..256
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 528..586
FT /note="Signal recognition particle SRP72 subunit RNA-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF08492"
FT REGION 524..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..674
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 74911 MW; 6FD9707F29CCED0B CRC64;
MSSGGGSVDS LWTEVNRCGQ NGDFTRALKA VNKILHEVKE DVTALHCKIV CLVQNCSFKE
ALNVMNTYSK VLGSELIVFE KAYCEYRLNR VESALKTIES VSEQTDKLKE LYGQVLYRME
RYDECKAVYT DLIRNSQDEY EEERKTNLSA VVAAMSTWEK ASPDDLGLSE TTYELSYNAA
CTLIGRGQLT EALNKLQEAE ELCRVFFSED SDITEEDVES ELAVIHSQMA YIMQLQGRTE
EALQLYNQVI KLKPSDVGLL AVTANNIITI NKDQNVFDSK KKVKLTNADG VEYKLAKKQL
QAIEFNKALL AMYTNQADQC RKLSSGLQSQ NPGHPRPVLI QVAQLCREKQ HSKAIELLQR
FSDQHPDSAS GIKLTMAQLY LTQGHVTKAC DILRSIEDFK HKQGMISALV SMYSHEEDID
SAIDVFSQAI QYYQSEQPGS SVHLALVREA ADFKLKYGRK KEAITDLEQL WKQNTNDIHT
LAQLISAYSL VDQDKAKSLS KHLPSPESMS FNVDVDELEN SHGANYVRKK AAKVTGENLP
KEQGQGDVKK KKKKKKKGKL PKNYDPTANP DPERWLPMRE RTYYRGRKKG KKKEQVGKGT
QGATSGAASD LDASKTASSP PTSPRPGSAQ TSASTPAPAA SNVVPPRQQK PAAAGPGARK
KAPQKKKKGG KGGW
//
