ID A0A4W6C127_LATCA Unreviewed; 1106 AA.
AC A0A4W6C127;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Solute carrier family 12 member 7 {ECO:0000313|Ensembl:ENSLCAP00010005300.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSLCAP00010005300.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010005300.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010005300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A4W6C127; -.
DR Ensembl; ENSLCAT00010005434.1; ENSLCAP00010005300.1; ENSLCAG00010001650.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..292
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 412..657
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 693..811
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 816..958
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 987..1106
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 25..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 123261 MW; 16A5CB3430548889 CRC64;
MDRVQTSLIK TFTIILWCGK QRTYEPKTKS DGVPKENSPF INNTDNDKGN SYDGTNMALF
EEEMDSNPMV SSLLNKLANY TNLTQGAQEH EEADDDEGPK KKAVKSPQMG TFMGVYLPCL
QNILGVILFL RLTWIVGTAG ILESLAIVGL CCSCTMLTAI SMSAIATNGV VPAGGSYYMI
SRSLGPEFGG AVGLCFYLGT TFAGSMYILG TIEILLTYIV PKAAIFVAER KEDEVDALLN
NMRVYGTCCL ALMAVVVFVG VKYVNKLALV FLACVILSIL AIYAGVIKTI FEPPDFPVCM
LGNRTLQNHN FDKCLKTEII DNVTVTTKLW KLFCKGSELN ATCNEYFANN NVTLVQGIPG
LTSGVISENM WSEYGPLNML VENKKLPSLG GSDPAKDIYM PYVVNDITTF FTLVLFCVLV
YYYYGSNCIM AGSNRSGDLR DAQKSIPIGT ILAIATTSVI YITCVVLFGA CIEGVLLRDK
FGDSVKGNLV IGTLSWPSPW VIVIGSFFSC CGAGLQSLTG APRLLQAIAR DGIVPFLQVF
GHGKANGEPT WALLLTAAIC EIGILIASLD SVAPILSMFF LMCYLFVNLA CAVQTLLRTP
NWRPRFKYYH WALSFLGMSL CLALMFISSW YYAIVAMAIA SCIYKYIEYR GAEKEWARYA
LIRLEEAPPH TKNWRPQLLV LLNLDSDQGV KHPRLLSFTT QLKAGKGLTI VGNVLEGTYL
TKETESKRAE QNIKASMSAE RTKGFCHVVV SSNLRDGFSH LIQSAGLGGM KHNTVLMAWP
GTWRQSNDPQ SWRNFIETVR ETTAAHQALL VAKNVDSFPT NQDRLGEGTI DVWWVVHDGG
MLMLLPFLLR QHKVWRKCKM RIFTVAQMDD NSIQMKKDLQ MFLYHLRLDA EVEVVEMHDN
DISAFTYEKT LVMEQRTQML KQMQLSRTER EREIQSITDE SRSSIRRKNQ GAAQSTNLSR
QSSSVEDTQE DEVAQLIHDR NTASHATIND KADTGPERVH MTWTKDKLFT ERSRNRECNA
NVAVRDLFNM KPNQSNVRRM HTAVKLNEVV VNKSQGAHLV LLNMPGPPRN RGGDENYMEF
LEVLLEGLNR VLLVRGGGRE VITIYS
//
